Destruxin A

Destruxin A is a cyclic peptide characterized by an unusual 4-amino-4-deoxy-L-arabinose moiety. This compound is known for its ability to inhibit the polymerase chain reaction within cells and has demonstrated efficacy against various cancer cell lines, including those of human origin. Moreover, it has significant effects on the heart, such as causing congestive heart failure and arrhythmia, and it has been associated with the induction of cancerous growths in tissues. Additionally, destruxin A suppresses hemocyte production and exhibits toxicity towards Galleria mellonella larvae. It also acts as an analogue for chemical pesticides that activate signal pathways involved in cellular proliferation.

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Product Detail

Product Name	Destruxin A
CAS No.	6686-70-0
Catalog	ALKS6686700
Purity	≥ 97%
Appearance	White to off-white solid
Molecular Weight	577.71
Molecular Formula	C29H47N5O7
Structure Classification	Cyclopeptides
Solubility	DMSO: 10 mg/mL (17.31 mM; need ultrasonic and warming)
Storage	Sealed storage, away from moisture Powder: -80 °C, 2 years; -20 °C, 1 year In solvent: -80 °C, 6 months; -20 °C, 1 month

Bioactive Properties And Applications of Destruxin A

Insecticidal Activity

Destruxin A is primarily known for its potent insecticidal properties. It can disrupt the physiological functions of various insects, leading to paralysis and death. It has been used in biological control strategies against agricultural pests, reducing the reliance on chemical insecticides.

Antiviral Activity

Studies have shown that destruxin A exhibits antiviral properties. It has been found to inhibit the replication of certain viruses, making it a potential candidate for antiviral drug development.

Antitumor Activity

Destruxin A has demonstrated cytotoxic effects against various cancer cell lines. Research indicates that it can induce apoptosis (programmed cell death) in tumor cells, making it a promising compound for anticancer therapies.

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