Heterophyllin B

Heterophyllin B is a cyclic peptide, which is a type of compound consisting of amino acids linked in a circular sequence. These cyclic peptides are often found in various natural sources including plants, bacteria, and marine organisms. Specifically, heterophyllin B has been identified in certain cyanobacteria species and higher plants. The chemical structure of heterophyllin B is characterized by its cyclic peptide configuration, which lends the molecule a rigid and stable structure, often contributing to its bioactive properties. The presence of both hydrophobic and hydrophilic residues facilitates interactions with various biological molecules and membranes, making it an interesting subject for pharmacological studies.

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Product Detail

Product Name	Heterophyllin B
CAS No.	145459-19-4
Catalog	ALKS145459194
Purity	≥ 99%
Appearance	White to off-white solid
Molecular Weight	778.94
Molecular Formula	C40H58N8O8
Structure Classification	Cyclopeptides
Solubility	DMSO: 100 mg/mL (128.38 mM; need ultrasonic)
Storage	Powder: 4 °C, protect from light In solvent: -80 °C, 6 months; -20 °C, 1 month, protect from light

Bioactive Properties and Applications of Heterophyllin B

The bioactive properties of heterophyllin B are extensive and contribute to its potential applications in several fields of medicine and biotechnology:

Anticancer Activity

Heterophyllin B has shown considerable promise in the field of oncology. It has been evaluated for its anticancer properties, demonstrating the ability to inhibit the proliferation of cancer cells. The mechanism of action often involves inducing apoptosis (programmed cell death) and inhibiting angiogenesis (formation of blood vessels in tumors), thereby restricting tumor growth and metastasis.

Antimicrobial Properties

This cyclic peptide displays antimicrobial activity against a variety of pathogens. It has been effective against certain bacteria and fungi, making it a potential candidate for developing new antibiotics, especially in an era where antibiotic resistance is a growing concern.

Anti-Inflammatory Effects

Heterophyllin B has been investigated for its anti-inflammatory properties. It can modulate the immune response, reducing inflammation by inhibiting the production of pro-inflammatory cytokines and mediators. This makes it useful for treating inflammatory diseases and conditions.

Antioxidant Activity

The antioxidant properties of heterophyllin B have been explored, highlighting its capacity to neutralize free radicals and reduce oxidative stress. This is significant in the prevention and treatment of diseases where oxidative damage is a contributing factor, such as neurodegenerative diseases and cardiovascular conditions.

Neuroprotective Effects

Studies have suggested that heterophyllin B might have neuroprotective effects, potentially offering protection against neurotoxicity and neuronal damage. This could be beneficial in the context of neurodegenerative diseases like Alzheimer's and Parkinson's disease.

Anti-tumor and Cytotoxic Effects

Specific studies have reported cytotoxic effects of heterophyllin B against certain tumor cell lines. It can induce cell cycle arrest and apoptosis in cancer cells, making it a potential therapeutic agent for cancer treatment.

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