Himastatin

Himastatin is a natural product that is classified as a cyclic depsipeptide antibiotic. It was first isolated from the fermentation broth of the bacterium Streptomyces hygroscopicus. Himastatin has garnered interest in the scientific and medical communities due to its potent antimicrobial properties, particularly against Gram-positive bacteria. It is characterized by its complex cyclic structure, which includes peptide and ester linkages. The molecule itself is a large, cyclic depsipeptide, meaning it contains both amino acids and hydroxy acids in its ring structure, connected by peptide and ester (depsipeptide) bonds.

Alfa Chemistry provides high-quality himastatin and related product customization services.

Product Detail

Product Name	Himastatin
CAS No.	126775-74-4
Catalog	ALKS126775744
Molecular Weight	1485.68
Molecular Formula	C72H104N14O20
Structure Classification	Cyclopeptides

Bioactive Properties And Applications of Himastatin

Antibiotic Properties

One of the primary and most well-documented applications of himastatin is its function as an antibiotic. Laboratory studies have demonstrated that it has broad-spectrum antibiotic activity, being effective against a variety of Gram-positive and some Gram-negative bacteria. This makes it a compound of interest in the development of new antibiotics, particularly in the age of increasing antibiotic resistance.

Antitumor Activity

Himastatin has also been investigated for its anticancer properties. Early research has shown that it can inhibit the growth of certain cancer cell lines. Although the precise mechanism through which himastatin exerts its antitumor effects is not fully understood, it is believed to potentiate apoptosis (programmed cell death) and inhibit cellular proliferation. These properties make it a candidate for further study in oncology.

Potential Use in Combination Therapies

Given its dual antibacterial and antitumor activities, there is interest in exploring himastatin in combination therapies. For example, it might be used alongside other antibiotics to combat resistant bacterial infections or with other anticancer agents to enhance therapeutic efficacy.

Research Tool

Beyond its direct clinical applications, himastatin serves as a valuable research tool. Scientists use it to study the mechanisms of antibiotic resistance, microbial bioactivity, and the biochemistry of cyclic peptides. Insights gained from such research can inform the development of new drugs and therapeutic strategies.

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