Homoharringtonine (HHT), also known as omacetaxine mepesuccinate, is a naturally occurring alkaloid derived from the leaves of the Cephalotaxus species, particularly Cephalotaxus harringtonia. It has been used in traditional Chinese medicine for its anti-cancer properties and is now recognized for its potential in modern oncology.
Alfa Chemistry offers high-quality homoharringtonine for research and development purposes.
Product Detail
| Product Name | Homoharringtonine |
| CAS No. | 26833-87-4 |
| Catalog | ALKS26833874 |
| Molecular Weight | 545.61 |
| Molecular Formula | C29H39NO9 |
| Purity | ≥ 98% |
| Appearance | Colorless crystalline powder |
| Melting Point | 144 - 146 °C |
| Solubility | Hardly soluble in water, easily soluble in methanol, ethanol, chloroform, ether and other organic solvents |
| Application | Used for content determination, identification, pharmacological experiments, activity screening, etc. |
| Storage | Refrigerate at 4 °C, seal tightly, and avoid light (valid for 2 years under this condition) |
Applications of Homoharringtonine
Homoharringtonine has several therapeutic applications, particularly in the field of oncology:
- Chronic Myeloid Leukemia (CML): Homoharringtonine is particularly effective in the treatment of chronic myeloid leukemia (CML), especially in patients who are resistant to tyrosine kinase inhibitors (TKIs) like imatinib.
- Acute Myeloid Leukemia (AML): There is ongoing research into the use of homoharringtonine in treating acute myeloid leukemia (AML). Some studies have shown promising results, particularly in combination with other chemotherapeutic agents.
- Other Malignancies: Preliminary studies suggest potential efficacy in other hematologic malignancies and solid tumors. However, more research is needed to fully understand its role and effectiveness in these cancers.
Mechanism of Action
Homoharringtonine exhibits its anti-cancer effects primarily through the inhibition of protein synthesis. Its mechanism of action includes:
Inhibition of Ribosomal Function
Homoharringtonine binds to the A-site cleft of the ribosome, inhibiting the elongation phase of protein synthesis. This binding prevents the correct positioning of aminoacyl-tRNA, which is essential for the addition of amino acids to the growing polypeptide chain.
Induction of Apoptosis
By inhibiting protein synthesis, homoharringtonine leads to a decrease in the levels of key regulatory proteins required for cell survival and proliferation. This results in the induction of apoptosis, or programmed cell death, in cancer cells.
Effects on Cell Cycle
Homoharringtonine can also cause cell cycle arrest at the G1 phase, further contributing to its anti-proliferative effects.
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