Pristinamycin IA (Mikamycin B)

Pristinamycin IA, also known as mikamycin B, is a cycle-peptidic macrolactone antibiotic that belongs to the streptogramin group. It is one of the two principal components of pristinamycin, the other being pristinamycin IIA. It is produced by the bacterium Streptomyces pristinaespiralis. Pristinamycin IA is effective against Staphylococcus and Streptococcus.

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Product Detail

Product Name	Pristinamycin IA (Mikamycin B)
CAS No.	3131-03-1
Catalog	ALKS3131031
Purity	≥ 98%
Appearance	Light yellow to yellow solid
Molecular Weight	866.96
Molecular Formula	C45H54N8O10
Structure Classification	Cyclopeptides
Solubility	DMSO: 33.33 mg/mL (38.44 mM; need ultrasonic)
Storage	Powder: -20 °C, 3 years; 4 °C, 2 years In solvent: -80 °C, 2 years; -20 °C, 1 year

Applications of Pristinamycin IA

Pristinamycin IA has several important application areas, primarily focused on its role as an antibiotic in both human and veterinary medicine. Here are the key applications:

Human Medicine

Pristinamycin IA is utilized for a variety of bacterial infections, particularly when caused by resistant strains. It is effective against conditions such as cellulitis, abscesses, and wound infections, especially those caused by methicillin-resistant Staphylococcus aureus (MRSA). This antibiotic is effective for treating osteomyelitis and septic arthritis, particularly when these conditions are due to resistant bacteria like MRSA.

Veterinary Medicine

It has been used to treat bacterial infections in livestock, poultry, and other animals, including those affecting the respiratory tract, skin, and soft tissues. It is particularly effective against Gram-positive bacteria that infect animals.

Pharmaceutical Research and Development

Pristinamycin IA can be used in research focused on developing new antibiotic combinations and derivatives to enhance efficacy and reduce resistance development. Its structure and mechanism of action provide valuable insights for creating new therapeutic agents.

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