10-Nitrocamptothecin

Catalog Number	ACM104195611-1
CAS Number	104195-61-1
Structure
Synonyms	4-Ethyl-4-hydroxy-9-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Molecular Weight	393.3
InChI	InChI=1S/C20H15N3O6/c1-2-20(26)14-7-16-17-11(8-22(16)18(24)13(14)9-29-19(20)25)5-10-6-12(23(27)28)3-4-15(10)21-17/h3-7,26H,2,8-9H2,1H3
InChI Key	XLHNAFUKOSPOAT-UHFFFAOYSA-N
Purity	95%+
Complexity	861
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	0
Exact Mass	393.09608521
Heavy Atom Count	29
Hydrogen Bond Acceptor Count	7
Hydrogen Bond Donor Count	1
Monoisotopic Mass	393.09608521
PhysicalState	Powder
Rotatable Bond Count	1
Topological Polar Surface Area	126 Ų

Custom Q&A

What is the chemical formula of 10-Nitrocamptothecin?

The chemical formula of 10-Nitrocamptothecin is C20H15N3O6.

What is the molecular weight of 10-Nitrocamptothecin?

The molecular weight of 10-Nitrocamptothecin is 393.35.

What are some of the synonyms for 10-Nitrocamptothecin?

Some synonyms for 10-Nitrocamptothecin include RUBETICAN, CAMPTOTHECIN, 9-NITRO-20(S)-, and 9-NITRO-CPT.

What is the boiling point of 10-Nitrocamptothecin?

The boiling point of 10-Nitrocamptothecin is predicted to be 827.4±65.0 °C.

What are some of the usage and synthesis of 10-Nitrocamptothecin?

Studies have found that 10-Nitrocamptothecin can induce apoptosis and delay cell growth in S phase and G2M phase. It is also a prodrug for 9-aminocamptothecin and functions as an antineoplastic agent.

What is the role of 10-Nitrocamptothecin as per ChEBI?

According to ChEBI, 10-Nitrocamptothecin (Rubitecan) is a pyranoindolizinoquinoline that acts as an antineoplastic agent, DNA topoisomerase inhibitor, and a prodrug.

What is the density of 10-Nitrocamptothecin?

The predicted density of 10-Nitrocamptothecin is 1.63±0.1 g/cm3.

How does 10-Nitrocamptothecin inhibit cell growth?

10-Nitrocamptothecin inhibits cell growth throughout the cell cycle and is dose- and time-dependent.

What is the pka value of 10-Nitrocamptothecin?

The pka value of 10-Nitrocamptothecin is predicted to be 11.17±0.20.

What category does 10-Nitrocamptothecin fall under in terms of products?

10-Nitrocamptothecin falls under the category of Natural Anti-cancer Medical Materials and Its Derivatives.

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