3-(3-(3-Hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one

Catalog Number	ACM24159077
CAS Number	24159-07-7
Synonyms	Febrifugine
Molecular Weight	301.34
InChI	InChI=1S/C16H19N3O3/c20-11(8-14-15(21)6-3-7-17-14)9-19-10-18-13-5-2-1-4-12(13)16(19)22/h1-2,4-5,10,14-15,17,21H,3,6-9H2
InChI Key	FWVHWDSCPKXMDB-UHFFFAOYSA-N
Purity	95%+
Complexity	466
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	0
Exact Mass	301.14264148
Heavy Atom Count	22
Hydrogen Bond Acceptor Count	5
Hydrogen Bond Donor Count	2
Monoisotopic Mass	301.14264148
PhysicalState	Powder
Rotatable Bond Count	4
Topological Polar Surface Area	82 Ų

Custom Q&A

What is the chemical structure of Febrifugine?

The chemical structure of Febrifugine is 3-(3-(3-Hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one.

What is the molecular formula of Febrifugine?

The molecular formula of Febrifugine is C16H19N3O3.

What is the molecular weight of Febrifugine?

The molecular weight of Febrifugine is 301.34.

What is the melting point range of Febrifugine?

The melting point range of Febrifugine is 139-140°; mp 154-156°.

In what form does Febrifugine exist?

Febrifugine exists as a crystalline solid.

What is the boiling point of Febrifugine?

The predicted boiling point of Febrifugine is 508.2±60.0 °C.

What is the solubility of Febrifugine in DMF, DMSO, ethanol, and PBS?

Febrifugine is soluble in DMF: 1.5 mg/ml; DMSO: 3.0 mg/ml; Ethanol: 0.1 mg/ml; PBS (pH 7.2): 2.5 mg/ml.

What is the toxicity of Febrifugine in white mice when orally administered?

The LD50 orally in white mice for Febrifugine is 2.5-3.0 mg/kg.

What is the main usage of Febrifugine?

Febrifugine is a quinazolinone alkaloid with significant antimalarial and anticancerous efficacy.

Besides antimalarial and anticancer properties, what other functions does Febrifugine and its analogs have?

Febrifugine and its analogs also function as NRF2 inhibitors, have antimalarial properties, and can be used in the prevention of chicken coccidiosis.

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