Berberine chloride hydrate

Catalog Number	ACM141433605
CAS Number	141433-60-5
Structure
Synonyms	5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride hydrate
Molecular Weight	389.8
InChI	InChI=1S/C20H18NO4.ClH.H2O/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H;1H2/q+1;/p-1
InChI Key	BPNJXFPOPCFZOC-UHFFFAOYSA-M
Melting Point	204-206 °C
Purity	95%+
Complexity	488
Covalently-Bonded Unit Count	3
Defined Atom Stereocenter Count	0
Exact Mass	389.1030004
Heavy Atom Count	27
Hydrogen Bond Acceptor Count	6
Hydrogen Bond Donor Count	1
Monoisotopic Mass	389.1030004
PhysicalState	Solid
Rotatable Bond Count	2
Topological Polar Surface Area	41.8 Ų

Custom Q&A

What is the product name of Berberine chloride hydrate?

The product name of Berberine chloride hydrate is Berberine chloride hydrate.

Where is Berberine chloride hydrate commonly isolated from?

Berberine chloride hydrate is commonly isolated from Chinese herbal medicine Coptis chinensis.

What is the storage temperature recommended for Berberine chloride hydrate?

The recommended storage temperature for Berberine chloride hydrate is -20°C.

What is the solubility of Berberine chloride hydrate in DMSO?

Berberine chloride hydrate is at least 3.9 mg/mL (10.00 mM) soluble in DMSO.

What biological activity is associated with Berberine chloride hydrate?

Berberine chloride hydrate is commonly used as an antibiotic and induces reactive oxygen species (ROS) generation while inhibiting DNA topoisomerase.

Which cell lines were tested for the inhibitory effects of Berberine chloride hydrate on cell proliferation?

Four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29 were tested for the inhibitory effects of Berberine chloride hydrate on cell proliferation.

What was the effect of Berberine chloride hydrate on the cell cycle of LoVo cells?

Exposure to 40.0 μM of Berberine chloride hydrate induced G2/M-phase cell cycle arrest in LoVo cells.

What is the range of IC50 values for Berberine chloride hydrate on different cell lines?

The IC50 values for Berberine chloride hydrate ranged from 40.8±4.1 μM for LoVo cells to 98.6±2.9 μM for HCT116 cells.

What is the concentration range at which Berberine chloride hydrate inhibits cell proliferation?

Berberine chloride hydrate inhibits cell proliferation at concentrations ranging from 1.25 to 160 μM.

How does the protein expression of cyclin B1, cdc2, and cdc25c change in response to Berberine chloride hydrate treatment?

Berberine chloride hydrate suppresses cyclin B1, cdc2, and cdc25c protein expression, especially at higher doses such as 80.0 μM after 24 hours of treatment.

※ Please kindly note that our products are for research use only.