Berberine (chloride hydrate)

Catalog Number	ACM68030182
CAS Number	68030-18-2
Structure
Synonyms	Berberine hydrochloride monohydrate
Molecular Weight	389.8
InChI	InChI=1S/C20H18NO4.ClH.H2O/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H;1H2/q+1;/p-1
InChI Key	BPNJXFPOPCFZOC-UHFFFAOYSA-M
Purity	95%+
Complexity	488
Covalently-Bonded Unit Count	3
Defined Atom Stereocenter Count	0
Exact Mass	389.1030004
Heavy Atom Count	27
Hydrogen Bond Acceptor Count	6
Hydrogen Bond Donor Count	1
Monoisotopic Mass	389.1030004
PhysicalState	Powder
Rotatable Bond Count	2
Topological Polar Surface Area	41.8 Ų

Custom Q&A

What is the chemical formula of Berberine chloride hydrate?

The chemical formula of Berberine chloride hydrate is C20H20ClNO5.

What is the molecular weight of Berberine chloride hydrate?

The molecular weight of Berberine chloride hydrate is 389.83.

Where is Berberine chloride hydrate commonly isolated from?

Berberine chloride hydrate is commonly isolated from Chinese herbal medicine Coptis chinensis.

What is the storage temperature recommended for Berberine chloride hydrate?

The storage temperature recommended for Berberine chloride hydrate is -20°C.

How is Berberine chloride hydrate soluble in DMSO?

Berberine chloride hydrate is soluble in DMSO: ≥ 3.9 mg/mL (10.00 mM).

What biological activity is associated with Berberine chloride hydrate?

Berberine chloride hydrate is known to induce reactive oxygen species (ROS) generation and inhibit DNA topoisomerase.

How does Berberine chloride hydrate affect the proliferation of colorectal carcinoma cell lines in vitro?

Berberine chloride hydrate has potential inhibitory effects on the proliferation of colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29.

What is the IC50 range for the inhibition of proliferation in four colorectal carcinoma cell lines by Berberine chloride hydrate?

The IC50 range for the inhibition of proliferation in four colorectal carcinoma cell lines by Berberine chloride hydrate ranges from 40.8±4.1 μM (LoVo) to 98.6±2.9 μM (HCT116).

How does Berberine chloride hydrate affect cell cycle progression in LoVo cells?

Exposure to 40.0 μM of Berberine chloride hydrate induced G2/M-phase cell cycle arrest in LoVo cells.

What proteins does Berberine chloride hydrate suppress in colorectal carcinoma cell lines after 24 hours?

Berberine chloride hydrate suppresses cyclin B1, cdc2, and cdc25c protein expression after 24 hours in colorectal carcinoma cell lines.

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