Bulleyaconitine A

Catalog Number	ACM107668791-1
CAS Number	107668-79-1
Structure
Description	Bulleyaconitine A is a diterpenoid alkaloid that has been isolated from the Chinese herb, Bulleya. It is a potent κ-opioid receptor agonist and was found to have cytotoxic effects on rat liver microsomes. Bulleyaconitine A also has significant anti-inflammatory properties and inhibits the production of prostaglandins in vitro. This compound has been shown to induce apoptosis in cancer cells by inhibiting cyclase activity, which may be due to its ability to inhibit protein synthesis. In addition, bulleyaconitine A has been shown to inhibit bone resorption and promote bone formation, as well as reduce acute toxicities when administered orally or intraperitoneally. The optimum extraction process for bulleyaconitine A is an ethanol/water mixture followed by column chromatography with silica gel or alumina as the adsorbent material.
Molecular Weight	627.76 g/mol
Molecular Formula	C35H49NO9
Canonical SMILES	CCN1C[C@@]2(CC[C@@H]([C@@]34[C@@H]2[C@H]([C@H](C31)[C@]5(C[C@@H]([C@]6(C[C@@H]4[C@@H]5[C@H]6C(=O)C7=CC=C(C=C7)OC)O)OC)OC(=O)C)OC)OC)COC
Storage	store at 10℃-25℃
MDL Number	MFCD01714791

Custom Q&A

What is the molecular formula of Bulleyaconitine A?

The molecular formula of Bulleyaconitine A is C35H49NO10.

What is the appearance of Bulleyaconitine A?

Bulleyaconitine A appears as a white powder.

In which region was Bulleyaconitine A first extracted from an herb called dianxi dula?

Bulleyaconitine A was first extracted from an herb called dianxi dula in the west of Yunnan.

What are the physical properties of Bulleyaconitine A in terms of solubility?

Bulleyaconitine A is soluble in methanol, ethanol, chloroform, and ether; insoluble in water; and easily dissolved in dilute hydrochloric acid or dilute sulfuric acid.

How does Bulleyaconitine A play a significant anti-inflammatory effect?

Bulleyaconitine A plays a significant anti-inflammatory effect by inhibiting the release of prostaglandins.

What is the trade name of Bulleyaconitine A?

Bulleyaconitine A obtained the trade name "Bulleyaconitine A."

What type of properties does Bulleyaconitine A possess in terms of local anesthesia?

Bulleyaconitine A possesses long-lasting local anaesthetic properties.

How is Bulleyaconitine A used in China?

Bulleyaconitine A is commonly used in China as a traditional medicine.

How does Bulleyaconitine A achieve its analgesic effect?

Bulleyaconitine A achieves its analgesic effect by effectively reducing sodium ion current, which is the electrophysiological basis on which pain conduction is dependent.

In which types of diseases has Bulleyaconitine A shown curative effects and clinical promotion?

Bulleyaconitine A has shown exact curative effects and rapid clinical promotion in chronic disease and rheumatic immune disease.

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