Celastrol

Catalog Number	ACM34157830-2
CAS Number	34157-83-0
Structure
Synonyms	Tripterine
IUPAC Name	(2R,4aS,6aR,6aS,14aS,14bR)-10-Hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid
Molecular Weight	450.6
Molecular Formula	C29H38O4
Canonical SMILES	CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O
InChI	InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
InChI Key	KQJSQWZMSAGSHN-JJWQIEBTSA-N
Melting Point	185-200 °C
Purity	98%+(HPLC)
Solubility	Soluble in methanol, ethanol, acetone, ethyl acetate, and chloroform, insoluble in water.
Appearance	Red needle-like crystals
Storage	Store at 4 °C, sealed, away from light (valid for 2 years under this condition).
Complexity	1100
Exact Mass	450.27700969
Heavy Atom Count	33
Isomeric SMILES	CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O
Monoisotopic Mass	450.27700969
Topological Polar Surface Area	74.6Ų

Custom Q&A

What is the chemical formula of Celastrol?

The chemical formula of Celastrol is C29H38O4.

What are the synonyms for Celastrol?

The synonyms for Celastrol include TRIPTERIN, and 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oicacid.

What is the melting point of Celastrol?

The melting point of Celastrol is 219-230°C.

What are the pharmacological effects of Celastrol?

Celastrol has antioxidant, anti-cancer neovascularization, anti-rheumatoid, cytotoxic, immune regulating, anti-inflammatory, anti-oxidation, immuno-suppressive, anti-arthritic, and anti-angiogenic effects.

How is Celastrol stored?

Celastrol is stored at a temperature of -20°C.

What is the Hazard Code for Celastrol?

The Hazard Code for Celastrol is T.

What are some uses of Celastrol?

Celastrol can be used as an antioxidant, as an antineoplastic, as a NO synthesis inhibitor, and as a chaperone stimulant.

What biological activity does Celastrol exhibit?

Celastrol is an antioxidant and anti-inflammatory agent. It inhibits lipid peroxidation in mitochondria and inhibits TNF-α-induced NF κB activation.

How does Celastrol induce cell death in cancer cells?

Celastrol induces UPR-dependent cell death in cancer cells.

What is the main application of Celastrol?

The main application of Celastrol is as an effective proteasome inhibitor, which can induce apoptosis of cancer cells through inhibiting proteasome activity.

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