Cephalotaxine

Catalog Number	ACM24316196-1
CAS Number	24316-19-6
Description	Cephalotaxlen ((-)-Cephalotaxine) is an alkaloid that can be isolated from Cephalotaxus fortunei, with antileukemic and antiviral activities. Cephalotaxlen has anti-ZIKV (Zika virus) activity.
Synonyms	(1S,3aR,14bβ)-1,5,6,8,9,14b-Hexahydro-2-methoxy-4H-cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1α-ol
IUPAC Name	(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-ol
Molecular Weight	315.36
Molecular Formula	C18H21NO4
Canonical SMILES	COC1=C[C@]23CCCN2CCC4=CC5=C(C=C4[C@@H]3[C@@H]1O)OCO5
InChI	InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3/t16-,17-,18+/m1/s1
InChI Key	YMNCVRSYJBNGLD-KURKYZTESA-N
Boiling Point	495.2±45.0 °C
Melting Point	131-132 °C
Purity	98%
Density	1.38±0.1 g/ml
Appearance	Powder
Storage	Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
Complexity	523
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	3
Exact Mass	315.14705815
Heavy Atom Count	23
Hydrogen Bond Acceptor Count	5
Hydrogen Bond Donor Count	1
Isomeric SMILES	COC1=C[C@]23CCCN2CCC4=CC5=C(C=C4[C@@H]3[C@@H]1O)OCO5
Monoisotopic Mass	315.14705815
PhysicalState	Solid
Rotatable Bond Count	1
Topological Polar Surface Area	51.2 Ų

Custom Q&A

What is the chemical formula for CEPHALOTAXINE?

The chemical formula for CEPHALOTAXINE is C21H42O3.

At what temperature does CEPHALOTAXINE melt?

CEPHALOTAXINE melts at a temperature of 131-134°C.

How should CEPHALOTAXINE be stored?

CEPHALOTAXINE should be stored in a refrigerator.

What is the solubility of CEPHALOTAXINE?

CEPHALOTAXINE is soluble in Chloroform and Methanol.

What color is CEPHALOTAXINE in its solid form?

CEPHALOTAXINE is white in color in its solid form.

Where is CEPHALOTAXINE naturally occurring?

CEPHALOTAXINE is a naturally occurring benzazepine alkaloid isolated from Cephalotaxus harringtonia.

What are some uses of cephalotaxine alkaloids?

Cephalotaxine alkaloids are used as an antiangiogenic agent for the treatment of angiogenic diseases and as antiviral and antitumor agents.

What properties have ester derivatives of cephalotaxine shown?

Ester derivatives of cephalotaxine have shown antiviral, antitumor, and anticancer properties.

What are some examples of cephalatoxin esters that have shown significant activity against leukemia?

Examples of cephalatoxin esters include harringtonine, sioharringtonine, and homoharringtonine, which have shown significant activity against leukemia.

What reference discusses the antitumor alkaloids from Cephalotaxus harringtonia?

The antitumor alkaloids from Cephalotaxus harringtonia are discussed in the reference by R. G. Powell, D. Weisleder, C. R. Smith, Jr. (1972) in the Journal of Pharmaceutical Sciences.

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