Cepharanthine

Catalog Number	ACM481492-2
CAS Number	481-49-2
Structure
Description	Competes with eNOS for binding to HSP90α
Synonyms	Ex Cepharantha tuber
IUPAC Name	(14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene
Molecular Weight	606.71 g/mol
Molecular Formula	C37H38N2O6
Canonical SMILES	CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
InChI	InChI=1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1
InChI Key	YVPXVXANRNDGTA-WDYNHAJCSA-N
Melting Point	145-155 °C
Purity	98%
Appearance	Solid
Storage	store at 2℃-8℃
Harmonized Tariff Code	UK: 2939990090 -
Hydrogen Bond Acceptor Count	8
Hydrogen Bond Donor Count	0
Isomeric SMILES	CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
MDL Number	MFCD00210482

Custom Q&A

What is the chemical formula of Cepharanthine?

The chemical formula of Cepharanthine is C37H38N2O6.

What are the synonyms for Cepharanthine?

The synonyms for Cepharanthine include Cepharanthin, CEPHARANTHINE, and OXYACANTHAN.

What is the solubility of Cepharanthine in DMSO?

Cepharanthine is soluble in DMSO at a concentration of 35 mg/mL.

What is the proposed pKa value of Cepharanthine?

The predicted pKa value of Cepharanthine is 7.61±0.20.

What is the major clinical use of Cepharanthine?

The major clinical use of Cepharanthine is to improve immunity impaired by chemotherapy or radiotherapy in tumor patients.

What is the biological activity of Cepharanthine against viruses?

Cepharanthine inhibits HIV-1 replication and displays potent activity against SARS coronavirus, HSV-1, and coxsackie B3.

In which plant is Cepharanthine naturally found?

Cepharanthine is naturally found in the Stephania cepharantha Hayata plant.

What is the pharmacological effect of Cepharanthine in cancer treatment?

Cepharanthine is a good antitumor drug sensitizer that can improve the efficacy of antitumor drugs and reduce their side effects.

What was the original use of Stephania japonica in traditional Chinese medicine?

Stephania japonica was used to treat tuberculosis and other consumptive diseases in traditional Chinese medicine.

What are the common reported side effects of Cepharanthine?

Common reported side effects of Cepharanthine include loss of appetite, discomfort in the stomach, rash/eruption, itch, nausea, diarrhea, headache, dizziness, swelling in face/hands/feet, and irregular menstruation.

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