Colchicine

Catalog Number	ACM64868-1
CAS Number	64-86-8
Description	Used as gout medication; anti-inflammatory
Molecular Weight	399.44 g/mol
Molecular Formula	C22H25NO6
Canonical SMILES	CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
Storage	store at <-15℃, protect from light
Harmonized Tariff Code	Switzerland: 29093099 - USA: 2909306000 - Slovakia: 2909309090 - UK: 2909309000 - China: 2909309090

Custom Q&A

What is the chemical formula of colchicine?

The chemical formula of colchicine is C22H25NO6.

What is the boiling point of colchicine?

The boiling point of colchicine is approximately 522.37°C.

What are the hazardous characteristics of colchicine?

Colchicine can be metabolized in vivo to become oxydicolchicine, which has strong toxicity. It can cause irritation to the digestive tract, inhibit blood cells, and lead to neutropenia deficiency and aplastic anemia.

What is the LD50 of colchicine in rats?

The LD50 of colchicine in rats is 1.6 mg/kg when administered intravenously.

What are the side effects of colchicine?

Side effects of colchicine can include gastrointestinal reactions such as nausea, abdominal pain, and diarrhea, as well as blood system reactions like agranulocytosis and thrombocytopenia.

How is colchicine used in the treatment of acute gout?

Colchicine has a good efficacy in treating acute gout by inhibiting white blood cells and proliferation activities, reducing inflammation caused by uric acid crystals, and providing anti-inflammatory effects.

What are the storage properties of colchicine?

Colchicine should be stored at 2-8°C and is considered stable but light sensitive. It is incompatible with strong oxidizing agents.

How is colchicine metabolized in the body?

Colchicine is mostly metabolized by the liver, with the metabolite and the prototype drug excreted in bile and reabsorbed through the intestinal tract.

What is the water solubility of colchicine?

Colchicine has a water solubility of 45 g/L at 20°C.

What are the different uses of colchicine?

Colchicine is used as an anti-gout drug, for treating acute gouty arthritis, preventing recurrent episodes of acute gouty arthritis, and in the treatment of various cancers such as breast cancer and skin cancer.

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