Conessine

Catalog Number	ACM546065-1
CAS Number	546-06-5
Description	Conessine is a natural compound that inhibits the ubiquitin ligase, which is an enzyme involved in protein degradation. It has been shown to have inhibitory properties on bone cancer and melanogenesis. Conessine has also been found to be active against infectious diseases such as tuberculosis and malaria. The inhibitory effects of conessine are mediated by its ability to bind to the substrate-binding site of the ubiquitin ligase. This binding prevents the ubiquitin ligase from binding with other proteins and then initiating their degradation. Conessine also binds to steroidal alkaloids and multidrug efflux pumps, which may account for its pharmacokinetic properties.
Synonyms	3-Beta-(dimethylamino)con-5-enine
Molecular Weight	356.59 g/mol
Molecular Formula	C24H40N2
Canonical SMILES	C[C@H]1[C@H]2CC[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23CN1C)N(C)C
InChI	InChI=1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1
InChI Key	GPLGAQQQNWMVMM-MYAJQUOBSA-N
Purity	95%+
Storage	store at 2℃-8℃
Complexity	609
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	8
Exact Mass	356.319149284
Harmonized Tariff Code	Switzerland: 29397900 - USA: 2939790000 - Slovakia: 2939791000 - UK: 2939790000 - China: 2939799099
Heavy Atom Count	26
Hydrogen Bond Acceptor Count	2
Hydrogen Bond Donor Count	0
Isomeric SMILES	C[C@H]1[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3CC=C5[C@@]4(CC[C@@H](C5)N(C)C)C)CN1C
MDL Number	MFCD00016752
Monoisotopic Mass	356.319149284
PhysicalState	Powder
Rotatable Bond Count	1
Topological Polar Surface Area	6.5 Ų

Custom Q&A

What is the chemical formula of Conessine?

The chemical formula of Conessine is C24H40N2.

What is the molecular weight of Conessine?

The molecular weight of Conessine is 356.59.

What are some synonyms for Conessine?

Some synonyms for Conessine include NERVINE, NERIINE, and WRIGHTINE.

What is the melting point of Conessine?

The melting point of Conessine is 126-127°C.

How does Conessine appear in its powder form?

Conessine appears as a white to tan powder.

What are some safety hazards associated with Conessine?

Conessine is associated with risk statements 36/37/38 and has safety statements 26.

What is the usage of Conessine?

Conessine can be used as an antiamebic, antibacterial, antineoplastic, and local anesthetic.

What is the biological activity of Conessine?

Conessine is a potent and selective histamine H3 receptor antagonist.

How does Conessine need to be stored?

Conessine needs to be stored at room temperature.

What is the solubility of Conessine in ethanol?

Conessine is soluble in ethanol at a concentration of at least 2mg/mL.

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