Cotarnine iodide

Catalog Number	ACM30936277-1
CAS Number	30936-27-7
Structure
Description	Cotarnine iodide is the major active alkaloid of anhalonium lewinii, a member of the order Piperales. Cotarnine iodide is a bisbenzylisoquinoline that contains an isoquinoline nucleus. It is synthesized from phenethylamines and anhalonium, which are also isoquinoline derivatives. Cotarnine iodide inhibits the synthesis of neurotransmitters such as acetylcholine in the central nervous system and has physiological effects such as sedation and muscle relaxation. It also causes closure of the pupil by blocking acetylcholinesterase activity. Cotarnine iodide binds to the nicotinic receptor sites on postganglionic neurons and blocks acetylcholinesterase activity, leading to a build-up of acetylcholine in these nerves. This can lead to paralysis of skeletal muscles by blocking transmission at neuromuscular junctions.
Synonyms	7,8-Dihydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
Molecular Weight	347.15 g/mol
Molecular Formula	C12H14INO3
Canonical SMILES	C[N+]1=CC2=C(C3=C(C=C2CC1)OCO3)OC.[I-]
Storage	store at <-15℃
Harmonized Tariff Code	Switzerland: 29214920 - USA: 2921494500 - Slovakia: 2921490065 - UK: 2921490000 - China: 2921499090
MDL Number	MFCD03819122

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