Cyclopamine

Catalog Number	ACM4449518-1
CAS Number	4449-51-8
Structure
Synonyms	11-Deoxojervine
IUPAC Name	(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-Tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
Molecular Weight	411.6
Molecular Formula	C27H41NO2
Canonical SMILES	CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
InChI	InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1
InChI Key	QASFUMOKHFSJGL-LAFRSMQTSA-N
Melting Point	224-227 °C
Purity	99%+(HPLC)
Appearance	White powder
Storage	Store at 4 °C, sealed, away from light (valid for 2 years under this condition).
Complexity	801
Exact Mass	411.313729551
Heavy Atom Count	30
Isomeric SMILES	C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1
Monoisotopic Mass	411.313729551
Topological Polar Surface Area	41.5Ų

Custom Q&A

What is the chemical name of Cyclopamine?

The chemical name of Cyclopamine is Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol.

What is the CAS number of Cyclopamine?

The CAS number of Cyclopamine is 4449-51-8.

What is the molecular formula of Cyclopamine?

The molecular formula of Cyclopamine is C27H41NO2.

At what temperature does Cyclopamine melt?

Cyclopamine has a melting point of 236-238°C.

What is the solubility of Cyclopamine in DMSO?

Cyclopamine is soluble in DMSO.

What are the safety statements associated with Cyclopamine?

The safety statements associated with Cyclopamine are 22-24/25.

What is the main source of Cyclopamine?

Cyclopamine is mainly isolated from the Veratrum plant.

What pathway does Cyclopamine inhibit?

Cyclopamine inhibits the Smoothened (Smo) protein in the Hedgehog signaling pathway.

What are some potential applications of Cyclopamine in the treatment of cancer?

Cyclopamine has shown potential as an anti-tumor drug in the treatment of pancreatic cancer, bile duct cancer, ovarian cancer, liver cancer, among others.

What are some other biological activities of Cyclopamine?

Cyclopamine is also known for depleting stem-like cancer cells in glioblastoma, blocking tumor engraftment, inducing differentiation of human embryonic stem cells, and inhibiting Hedgehog signaling pathway activation.

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