Demethyleneberberine

Catalog Number	ACM25459910-1
CAS Number	25459-91-0
Structure
Description	Demethyleneberberine is a natural drug that inhibits the Cox-2 enzyme, which is involved in the production of prostaglandins. It also inhibits the activity of various receptors and has been shown to decrease the level of dextran sulfate in blood plasma. Demethyleneberberine has been shown to have hypoglycemic effects by improving insulin sensitivity and increasing glucose uptake. This drug has been found to be useful for treating bowel disease, as well as metabolic disorders such as congestive heart failure. Demethyleneberberine is a pro-apoptotic protein that binds to polycyclic aromatic hydrocarbons and coumarin derivatives through its polyphenolic group, which are metabolized by oxidative reactions or reductive reactions. These reactions can be analyzed using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) methods.
Synonyms	2,3-Dihydroxy-9,10-dimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium
IUPAC Name	9,10-Dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol
Molecular Weight	324.35 g/mol
Molecular Formula	C19H18NO4
Canonical SMILES	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)O)OC
InChI	InChI=1S/C19H17NO4/c1-23-18-4-3-11-7-15-13-9-17(22)16(21)8-12(13)5-6-20(15)10-14(11)19(18)24-2/h3-4,7-10,22H,5-6H2,1-2H3/p+1
InChI Key	HVTCKKMWZDDWOY-UHFFFAOYSA-O
Purity	98%
Appearance	Powder
Storage	store at 10℃-25℃, close container well
Complexity	447
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	0
Exact Mass	324.12358306
Harmonized Tariff Code	Switzerland: 29397900 - USA: 2939790000 - Slovakia: 2939799090 - UK: 2939799090 - China: 2939799099
Heavy Atom Count	24
Hydrogen Bond Acceptor Count	4
Hydrogen Bond Donor Count	2
MDL Number	MFCD22417296
Monoisotopic Mass	324.12358306
PhysicalState	Powder
Rotatable Bond Count	2
Topological Polar Surface Area	62.8 Ų

Custom Q&A

What is the chemical formula of DeMethyleneberberine?

The chemical formula of DeMethyleneberberine is C19H18NO4+.

What is the molecular weight of DeMethyleneberberine?

The molecular weight of DeMethyleneberberine is 324.36.

What are some synonyms for DeMethyleneberberine?

Some synonyms for DeMethyleneberberine include dibenzo[a,g]quinoliziniuM, 2,3-dihydroxy-9,10-diMethoxy, and 2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquinolino.

In what product categories does DeMethyleneberberine fall under?

DeMethyleneberberine falls under alkaloids, reference standards from Chinese medicinal herbs, chemical reagent, pharmaceutical intermediate, phytochemical, and standardized herbal extract.

What is the storage temperature recommended for DeMethyleneberberine?

The recommended storage temperature for DeMethyleneberberine is 4°C, and it should be protected from light.

In what form does DeMethyleneberberine exist?

DeMethyleneberberine exists in powder form.

What is the solubility of DeMethyleneberberine in DMSO?

The solubility of DeMethyleneberberine in DMSO is 33.33 mg/mL, however, Ultrasonic is needed.

What are the uses of Demethyleneberberine?

Demethyleneberberine is a naturally occurring alkaloid in plants that displays anti-adipogenic effects and is shown to alleviate IBS.

What are some of the targets of DeMethyleneberberine?

Some targets of DeMethyleneberberine include P450 (e.g. CYP17), HIF, and NOS.

What is the CAS number of DeMethyleneberberine?

The CAS number of DeMethyleneberberine is 25459-91-0.

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