Gefitinib

Catalog Number	ACM184475352-2
CAS Number	184475-35-2
Synonyms	Iressa
IUPAC Name	N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Molecular Weight	446.9
Molecular Formula	C22H24ClFN4O3
Canonical SMILES	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
InChI	InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
InChI Key	XGALLCVXEZPNRQ-UHFFFAOYSA-N
Melting Point	194-198 °C
Purity	98%+(HPLC)
Appearance	Yellow crystalline powder
Storage	Store at 4 °C, sealed, away from light (valid for 2 years under this condition).
Complexity	545
Exact Mass	446.1520965
Heavy Atom Count	31
Monoisotopic Mass	446.1520965
Topological Polar Surface Area	68.7Ų

Custom Q&A

What is the chemical formula of Gefitinib?

The chemical formula of Gefitinib is C22H24ClFN4O3.

What is the melting point of Gefitinib?

The melting point of Gefitinib is 119-120°C.

How is Gefitinib primarily metabolized in the liver?

Gefitinib is primarily metabolized in the liver through the cytochrome P450 enzyme CYP3A4.

What are some common adverse reactions of Gefitinib?

Common adverse reactions of Gefitinib include diarrhea, nausea, rashes, acne, vomiting, and feebleness.

Who should avoid taking Gefitinib according to the warnings and precautions?

Pregnant women should avoid taking Gefitinib according to the warnings and precautions.

What is the bioavailability of Gefitinib after a single oral 250mg dose?

The bioavailability of a single oral 250mg dose of Gefitinib is nearly 60%.

What is the BOiling point of Gefitinib?

The boiling point of Gefitinib is 586.8±50.0 °C (Predicted).

What is the brand name of Gefitinib?

The brand name of Gefitinib is Iressa.

What are the indications for the use of Gefitinib?

Gefitinib is used for the treatment of non-small cell lung cancer.

What is the storage temperature recommended for Gefitinib?

Gefitinib should be stored at room temperature.

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