Harringtonine

Catalog Number	ACM26833852-1
CAS Number	26833-85-2
Structure
Description	Harringtonine is a natural compound that has been shown to inhibit the activity of DNA polymerase. It is a potent inhibitor of protein genes and has minimal toxicity to cells in culture. Harringtonine binds to the active site of DNA polymerase, preventing it from catalyzing the addition of nucleotides to the 3' end of dsDNA. This inhibition prevents replication and transcription, which are vital for cell growth and proliferation. The synergistic effect between harringtonine and ginsenoside RG3 has been shown in experiments with K562 cells.
Synonyms	3-4-Methyl-(2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioatecephalotaxine
Molecular Weight	531.59 g/mol
Molecular Formula	C28H37NO9
Canonical SMILES	CC(C)(CC[C@@](CC(=O)OC)(C(=O)O[C@H]1[C@H]2C3=CC4=C(C=C3CCN5[C@@]2(CCC5)C=C1OC)OCO4)O)O
Storage	store at <-15℃, close container well, keep dry
Harmonized Tariff Code	Switzerland: 29397900 - USA: 2939790000 - Slovakia: 2939799090 - UK: 2939490000 - China: 2939799099
MDL Number	MFCD28978177

Custom Q&A

What is the chemical formula for Harringtonine?

The chemical formula for Harringtonine is C28H37NO9.

What is the molecular weight of Harringtonine?

The molecular weight of Harringtonine is 531.6.

At what temperature does Harringtonine melt?

Harringtonine melts at a temperature of 73-75℃.

What is the boiling point of Harringtonine?

The predicted boiling point of Harringtonine is 679.4±55.0 °C.

In what form is Harringtonine commonly found?

Harringtonine is commonly found in the form of a crystalline solid.

What is the storage temperature recommended for Harringtonine?

The recommended storage temperature for Harringtonine is 2-8°C.

What is the solubility of Harringtonine in DMF, DMSO, Ethanol, and Ethanol:PBS (pH 7.2) (1:1)?

Harringtonine is soluble in DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 25 mg/ml; and Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml.

What is the HazardClass of Harringtonine?

The HazardClass of Harringtonine is 6.1(a).

What is the main usage of Harringtonine?

Harringtonine is a specific anti-leukemia drug.

What is the chemical property of Harringtonine?

Harringtonine is a white solid with significant antitumor activities.

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