Histamine Dihydrochloride

Histamine Dihydrochloride

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Catalog Number ACM56928
CAS Number 56-92-8
Structure
Description Histamine dihydrochloride (INN, trade name Ceplene) is a salt of histamine which is used as a drug for the prevention of relapse in patients diagnosed with acute myeloid leukemia (AML).It is an FDA approved active ingredient for topical analgesic use and is available in such products as Australian Dream Cream, which is used for the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, bruises, sprains, and strains.
Synonyms 2-(3H-Imidazol-4-yl)ethanamine dihydrochloride
IUPAC Name 2-(1H-imidazol-5-yl)ethanamine;dihydrochloride
Molecular Weight 184.07
Molecular Formula C5H11Cl2N3
Canonical SMILES C1=C(NC=N1)CCN.Cl.Cl
InChI InChI=1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
InChI Key PPZMYIBUHIPZOS-UHFFFAOYSA-N
Melting Point 249-252 °C (lit.)
Flash Point 180.3ºC
Purity 98%
Density 1.14 g/cm³
Solubility Methanol (Slightly, Heated), Water (Slightly)
Appearance White to off-white solid
Application Present in most mammalian tissues; primarily stored in mast cells and basophils. Exhibits multiple biological effects through at least 3 specific receptors. Induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter. Histamine has been identified as a bedbug pheromone.
Storage Refrigerator
Complexity 64.7
Covalently-Bonded Unit Count 3
Defined Atom Stereocenter Count 0
Exact Mass 183.0330028
Heavy Atom Count 10
HS Code 2933290090
Hydrogen Bond Acceptor Count 2
Hydrogen Bond Donor Count 4
MDL Number MFCD00012703
Monoisotopic Mass 183.0330028
PhysicalState Powder
Rotatable Bond Count 2
Topological Polar Surface Area 54.7 Ų

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