Histamine Dihydrochloride

Catalog Number	ACM56928
CAS Number	56-92-8
Structure
Description	Histamine dihydrochloride (INN, trade name Ceplene) is a salt of histamine which is used as a drug for the prevention of relapse in patients diagnosed with acute myeloid leukemia (AML).It is an FDA approved active ingredient for topical analgesic use and is available in such products as Australian Dream Cream, which is used for the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, bruises, sprains, and strains.
Synonyms	2-(3H-Imidazol-4-yl)ethanamine dihydrochloride
IUPAC Name	2-(1H-imidazol-5-yl)ethanamine;dihydrochloride
Molecular Weight	184.07
Molecular Formula	C5H11Cl2N3
Canonical SMILES	C1=C(NC=N1)CCN.Cl.Cl
InChI	InChI=1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
InChI Key	PPZMYIBUHIPZOS-UHFFFAOYSA-N
Melting Point	249-252 °C (lit.)
Flash Point	180.3ºC
Purity	98%
Density	1.14 g/cm³
Solubility	Methanol (Slightly, Heated), Water (Slightly)
Appearance	White to off-white solid
Application	Present in most mammalian tissues; primarily stored in mast cells and basophils. Exhibits multiple biological effects through at least 3 specific receptors. Induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter. Histamine has been identified as a bedbug pheromone.
Storage	Refrigerator
Complexity	64.7
Covalently-Bonded Unit Count	3
Defined Atom Stereocenter Count	0
Exact Mass	183.0330028
Heavy Atom Count	10
HS Code	2933290090
Hydrogen Bond Acceptor Count	2
Hydrogen Bond Donor Count	4
MDL Number	MFCD00012703
Monoisotopic Mass	183.0330028
PhysicalState	Powder
Rotatable Bond Count	2
Topological Polar Surface Area	54.7 Ų

Custom Q&A

What is the chemical formula of Histamine dihydrochloride?

The chemical formula of Histamine dihydrochloride is C5H11Cl2N3.

What are the synonyms of Histamine dihydrochloride?

The synonyms of Histamine dihydrochloride are TIMTEC-BB SBB003722, 2-[4-IMIDAZOYL]-ETHYLAMINE DIHYDROCHLORIDE, 2-(1H-IMIDAZOL-4-YL)-ETHYLAMINE 2HCL, and more.

What is the solubility of Histamine dihydrochloride in water?

Histamine dihydrochloride is soluble in water at a concentration of 0.1 g/mL.

What is the melting point of Histamine dihydrochloride?

The melting point of Histamine dihydrochloride is 249-252 °C.

How is Histamine dihydrochloride stored?

Histamine dihydrochloride should be stored at 2-8°C.

What is the biological activity of Histamine dihydrochloride?

Histamine dihydrochloride is an endogenous agonist at histamine receptors (H 1-4) and exhibits inflammatory, vasodilatory, and bronchoconstrictory activity.

How has Histamine dihydrochloride been used in research studies?

Histamine dihydrochloride has been used as an orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP), to determine its level in fish using HPLC, and to assess the tracheal response to antigens in guinea-pigs.

What are the safety statements associated with Histamine dihydrochloride?

The safety statements associated with Histamine dihydrochloride include S22, S26, S36/37/39, S45, S37, and S36/37.

What are the hazard codes for Histamine dihydrochloride?

The hazard codes for Histamine dihydrochloride are Xn and Xi.

What are the general uses of Histamine dihydrochloride?

Histamine dihydrochloride is present in most mammalian tissues, primarily stored in mast cells and basophils, and exhibits multiple biological effects through specific receptors. It induces bronchoconstriction and vasodilation, stimulates gastric acid secretion, and acts as a neurotransmitter.

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