Intermedine

Catalog Number	ACM10285060
CAS Number	10285-06-0
Structure
Description	Intermedine is a potent alkaloid that has been shown to inhibit angiogenesis in vitro and in vivo. It has been shown to have potential as a biomarker for myocardial infarcts and as a target for the treatment of cardiovascular disease. Intermedine has also been shown to inhibit the expression of inflammatory genes, including toll-like receptor (TLR) 2, TLR4, and TLR9, which activate proinflammatory cytokines and chemokines. Intermedine is also toxic when administered intravenously at high doses, so it should be used with caution.
Molecular Weight	299.36 g/mol
Molecular Formula	C15H25NO5
Canonical SMILES	C[C@H]([C@@](C(C)C)(C(=O)OCC1=CCN2[C@H]1[C@@H](CC2)O)O)O
Storage	store at <-15℃, close container well
Harmonized Tariff Code	Switzerland: 29397900 - USA: 2939790000 - Slovakia: 2939799090 - UK: 2939799090 - China: 2939799099

Custom Q&A

What are some synonyms for Intermedine?

Intermedine, melanotrophins, chromatophone hormone, pigment hormone

What are some other potential uses or effects of Intermedine based on the reference?

It is also referred to as a melanophore-affecting hormone and metanocyte-stimulating hormone.

What is the CAS number for Intermedine?

9002-79-3

What is the molecular formula for Intermedine?

C96H137O39N25S

In what type of plant is Intermedine found naturally?

Amsinckia intermedia Fisch & Mey, A. hispada (Ruiz et Pav.) Johnst., A. lycopsoides Lehm.

What is the optical rotation of Intermedine?

It is dextrorotatory with [α]20D + 4.0° (c 0.79, EtOH) and + 4.8° (c 2.39, EtOH).

What compounds are formed upon alkaline hydrolysis of Intermedine?

Retronecine and (+ )-trachelanthic acid

How is the structure of Intermedine confirmed?

By synthesis, with the spectra indicating that the alkaloid is present in the plant as a racemate

What is the reference mentioned in the text for more information on Intermedine?

Culvenor, Smith., Austral. 1. Chern., 19,1955 (1966)

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