Kukoamine A

Catalog Number	ACM75288969-1
CAS Number	75288-96-9
Description	Kukoamine A is a natural compound that has been shown to have biological properties, including iron homeostasis and the ability to inhibit neuronal death. Kukoamine A also inhibits the activity of several enzymes, such as phospholipase D, cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and protein kinase C. The apoptosis pathway is triggered by Kukoamine A when it binds to Fas-associated death domain protein (FADD) and tumor necrosis factor receptor 1 (TNFR1). Kukoamine A also has the ability to reduce liver steatosis and cure infectious diseases in animal models. It can also be used for drug control analysis or as a treatment for autoimmune diseases.
Synonyms	N1,N12-Bis(dihydrocaffeoyl) spermine
Molecular Weight	530.66 g/mol
Molecular Formula	C28H42N4O6
Canonical SMILES	C1=CC(=C(C=C1CCC(=O)NCCCNCCCCNCCCNC(=O)CCC2=CC(=C(C=C2)O)O)O)O
InChI	InChI=1S/C28H42N4O6/c33-23-9-5-21(19-25(23)35)7-11-27(37)31-17-3-15-29-13-1-2-14-30-16-4-18-32-28(38)12-8-22-6-10-24(34)26(36)20-22/h5-6,9-10,19-20,29-30,33-36H,1-4,7-8,11-18H2,(H,31,37)(H,32,38)
InChI Key	IOLDDENZPBFBHV-UHFFFAOYSA-N
Purity	95%+
Density	1.213±0.06 g/cm³ (20 ºC 760 Torr)
Complexity	601
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	0
Exact Mass	530.31043507
Harmonized Tariff Code	Switzerland: 29242920 - USA: 2924297790 - Slovakia: 2924290000 - UK: 2924290000 - China: 2924299099
Heavy Atom Count	38
Hydrogen Bond Acceptor Count	8
Hydrogen Bond Donor Count	8
MDL Number	MFCD29904538
Monoisotopic Mass	530.31043507
PhysicalState	Powder
Rotatable Bond Count	19
Topological Polar Surface Area	163 Ų

Custom Q&A

What is the chemical formula of kukoamine A?

The chemical formula of kukoamine A is C28H42N4O6.

What is the molecular weight of kukoamine A?

The molecular weight of kukoamine A is 530.66.

What is the boiling point of kukoamine A?

The boiling point of kukoamine A is predicted to be 872.1±65.0 °C.

What is the storage temperature recommended for kukoamine A?

The recommended storage temperature for kukoamine A is -20°C.

What is a common form in which kukoamine A is found?

Kukoamine A is found in the form of a crystalline solid.

What are the biological activities associated with kukoamine A?

Kukoamine A has diverse biological activities including anticancer, neuroprotective, and anti-inflammatory properties.

How does kukoamine A affect glioblastoma cells?

Kukoamine A inhibits colony formation of glioblastoma cells in a concentration-dependent manner.

How does kukoamine A affect cell cycle and apoptosis?

Kukoamine A halts the cell cycle at the G0/G1 phase and induces apoptosis at higher concentrations.

What enzyme does kukoamine A selectively inhibit?

Kukoamine A selectively inhibits trypanothione reductase, an enzyme that protects certain parasites from oxidative stress.

What is the main usage of kukoamine A?

Kukoamine A is used as a neuroprotective agent to prevent the loss of dopaminergic neurons in substantia nigra.

※ Please kindly note that our products are for research use only.