L-Dicentrine

Catalog Number	ACM28832077-1
CAS Number	28832-07-7
Structure
Description	L-Dicentrine is an alkaloid found in the Chinese herb Stephania. It has been shown to be a potent inhibitor of LPS-induced inflammatory response, which is caused by the bacterial endotoxin lipopolysaccharide. L-Dicentrine also has been shown to inhibit the production of inflammatory cytokines and chemokines, such as tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β). L-Dicentrine also inhibits 5HT2 receptors and has been shown to have anti-inflammatory effects on mouse tumor cells. This compound may also be beneficial for reducing atherosclerotic lesion formation in mice.
Synonyms	(7αR)-6,7,7α,8-Tetrahydro-10,11-dimethoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline9,10-Dimethoxy-1,2-(methylenediox y)-6α-β-aporphine
Molecular Weight	339.39 g/mol
Molecular Formula	C20H21NO4
Canonical SMILES	CN1CCC2=CC3=C(C4=C2[C@H]1CC5=CC(=C(C=C54)OC)OC)OCO3
InChI	InChI=1S/C20H21NO4/c1-21-5-4-11-7-17-20(25-10-24-17)19-13-9-16(23-3)15(22-2)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3/t14-/m1/s1
InChI Key	YJWBWQWUHVXPNC-CQSZACIVSA-N
Purity	95%+
Density	1.266±0.06 g/cm³ (20 ºC 760 Torr)
Storage	store at 10℃-25℃, close container well
Complexity	502
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	1
Exact Mass	339.14705815
Harmonized Tariff Code	Switzerland: 29397900 - USA: 2939790000 - Slovakia: 2939799090 - UK: 2939490090 - China: 2939799099
Heavy Atom Count	25
Hydrogen Bond Acceptor Count	5
Hydrogen Bond Donor Count	0
Isomeric SMILES	CN1CCC2=CC3=C(C4=C2[C@H]1CC5=CC(=C(C=C54)OC)OC)OCO3
MDL Number	MFCD31631137
Monoisotopic Mass	339.14705815
PhysicalState	Powder
Rotatable Bond Count	2
Topological Polar Surface Area	40.2 Ų

Custom Q&A

What is the chemical formula for L-DICENTRINE?

The chemical formula for L-DICENTRINE is C20H21NO4.

What is the molecular weight of L-DICENTRINE?

The molecular weight of L-DICENTRINE is 339.39.

What are some synonyms for L-DICENTRINE?

Some synonyms for L-DICENTRINE include Cepharanthine α-base, Eximine, and (R)-(-)-DICENTRINE.

What are the product categories that L-DICENTRINE falls under?

L-DICENTRINE falls under the product categories of Heterocycles, Aromatics, Inhibitors, Intermediates & Fine Chemicals, and Pharmaceuticals.

What is the boiling point of L-DICENTRINE?

The predicted boiling point of L-DICENTRINE is 480.7±45.0°C.

What is the density of L-DICENTRINE at 20°C and 760 Torr?

The density of L-DICENTRINE is 1.266±0.06 g/cm3 at 20°C and 760 Torr.

What is the pka value of L-DICENTRINE?

The predicted pka value of L-DICENTRINE is 6.65±0.20.

What is the usage of L-DICENTRINE?

L-DICENTRINE is a natural vascular alpha 1-adrenoceptor antagonist and a potential muscle relaxant. It has a protective effect on acute myocardial ischemia and anoxia lesion.

How does L-DICENTRINE inhibit the contraction of rat stomach muscle strips?

L-DICENTRINE inhibits the contraction of rat stomach muscle strips induced by 5-HT, histamine, K+, and Ca2+ after high K+ depolarization through non-competitive antagonism.

What potential therapeutic benefits have studies suggested for L-DICENTRINE?

Studies have suggested that L-DICENTRINE has potential therapeutic benefits in protecting against acute myocardial ischemia and anoxia lesions.

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