Linezolid

Catalog Number	ACM165800033
CAS Number	165800-03-3
Structure
Synonyms	Zyvox
IUPAC Name	N-[[(5S)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
Molecular Weight	337.35
Molecular Formula	C16H20FN3O4
Canonical SMILES	CC(=O)NCC1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCOCC3)F
InChI	InChI=1S/C16H20FN3O4/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-23-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1
InChI Key	TYZROVQLWOKYKF-ZDUSSCGKSA-N
Purity	98%+
Storage	Store in dry, low temperature, sealed, 2-8 °C.
Complexity	472
Exact Mass	337.14378429
Heavy Atom Count	24
Isomeric SMILES	CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCOCC3)F
Monoisotopic Mass	337.14378429
Topological Polar Surface Area	71.1Ų

Custom Q&A

What is the chemical formula of Linezolid?

The chemical formula of Linezolid is C16H20FN3O4.

What is the melting point of Linezolid?

The melting point of Linezolid is 176-178°C.

What are some synonyms for Linezolid?

Some synonyms for Linezolid include PNU 100766 and Linezolid-13C-d3.

What is the density of Linezolid?

The density of Linezolid is 1.302 ± 0.06 g/cm3.

What is the primary indication for Linezolid?

Linezolid is primarily indicated for the treatment of Gram-positive bacteria caused infections.

How is Linezolid classified in the Biopharmaceutics Classification System (BCS)?

Linezolid is classified as BCS Class 4.

What is the mechanism of action of Linezolid?

Linezolid inhibits bacterial protein synthesis by binding to a site on 23S ribosomal RNA of the 50S subunit, preventing further formation of a functional 70S initiation complex.

Which company developed and produced Linezolid?

Linezolid was developed and produced by the US Pharmacia & Upiohn company, which has been acquired by Pfizer.

How does Linezolid compare to vancomycin in terms of effectiveness?

In vitro studies showed that Linezolid was effective against staphylococcal, streptococcal, and pneumococcal infections at potency levels similar to vancomycin.

What is Linezolid used for in checkerboard-type drug combination MIC assay?

Linezolid has been used in checkerboard-type drug combination MIC assay to determine whether ivacaftor shows positive interaction with Linezolid.

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