(-)-Lycorine

Catalog Number	ACM476288
CAS Number	476-28-8
Description	(-)-Lycorine is a natural compound that belongs to the group of alkaloids. It is found in plants such as the wolfberry, and has shown inhibitory properties against squamous cell carcinoma. (-)-Lycorine has been shown to induce apoptosis in Hl-60 cells by inhibiting mitochondrial functions and triggering epithelial mesenchymal transition. This compound also inhibits opportunistic fungal growth, including Candida albicans and Saccharomyces cerevisiae. (-)-Lycorine has been shown to have cytotoxic effects on cancer tissues, which may be caused by its ability to inhibit complex enzymes involved in cancer cell proliferation. (-)-Lycorine is structurally related to lycorine, an alkaloid from the plant Lycopodium serratum that can promote pluripotent stem cells.
Synonyms	(1S,2S,12bS,12cS)-2,4,5,7,12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol
Molecular Weight	287.31 g/mol
Molecular Formula	C16H17NO4
Canonical SMILES	C1CN2CC3=CC4=C(C=C3[C@H]5[C@H]2C1=C[C@@H]([C@H]5O)O)OCO4
Storage	store at 2℃-8℃, close container well
Harmonized Tariff Code	Switzerland: 29062990 - USA: 2906296000 - Slovakia: 2934999090 - UK: 2906290000 - China: 2906299090
MDL Number	MFCD00221746

Custom Q&A

What is the chemical formula of lycorine?

The chemical formula of lycorine is C16H17NO4.

What is the melting point of lycorine?

The melting point of lycorine is 253-255°C (dec.).

What are some of the physical properties of lycorine?

Some physical properties of lycorine include its appearance as a colorless prismatic crystal, being insoluble in water, and having a melting point of 275-280°C.

What are the safety codes associated with lycorine?

The hazard code associated with lycorine is T, and the risk statements are 25.

What are the main active ingredients extracted from lycoris herbs?

The main active ingredients extracted from lycoris herbs are about 40 alkaloids, with galanthamine, lycorine, lycoramine, lycorenine, and crinine being the major effective medicinal ingredients.

How is lycorine used in traditional Chinese medicine (TCM)?

Lycorine is used in TCM for detoxication, easy expectoration, diuresis, emesis promotion, and against cancer.

What pharmacological activities and mechanisms have been explored for lycorine?

Recent studies have explored the effect of lycorine on the central nervous system, cardiovascular system, anti-inflammatory action, smooth muscle, emetic effect, antitumor effect, and antiparasitic properties.

What are the effects of lycorine on the central nervous system according to pharmacology studies?

Lycorine has been shown to accelerate mice's conditioned reflex of motor and defense nature, induce sedative effects, and extend the sleep time of certain drugs in animal models.

How is lycorine purified?

Lycorine can be purified by crystallizing it from MeOH, CHCl3/EtOH, pyridine, or EtOH, and can also be distilled under high vacuum.

What are some clinical uses of lycorine and its derivatives?

Clinical uses of lycorine and its derivatives include resistance to amebic protozoa, treatment of intraintestinal/extraintestinal amebiasis, antitumor effects, effects on the central nervous system, cardiovascular system, anti-inflammatory effects, smooth muscle stimulation, and emetic effects.

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