Masitinib

Catalog Number	ACM790299795
CAS Number	790299-79-5
Structure
Synonyms	Masitinib (AB1010)
IUPAC Name	4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide
Molecular Weight	498.64
Molecular Formula	C28H30N6OS
Canonical SMILES	CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5
InChI	InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32)
InChI Key	WJEOLQLKVOPQFV-UHFFFAOYSA-N
Purity	98%+
Storage	Store in dry, low temperature, sealed, 2-8 °C.
Complexity	696
Exact Mass	498.22018078
Heavy Atom Count	36
Monoisotopic Mass	498.22018078
Topological Polar Surface Area	102Ų

Custom Q&A

What is the chemical formula of Masitinib?

The chemical formula of Masitinib is C28H30N6OS.

What is the Melting point of Masitinib?

The melting point of Masitinib is 90-95°C.

What are some of the biological activities of Masitinib?

Masitinib is a novel Kit and PDGFRα/β inhibitor with IC50 of 200 nM and 540 nM/800 nM, respectively, however with weak inhibits on ABL and c-Fms.

How does Masitinib act in vitro?

Masitinib, at a concentration of ≤ 500 nM, is a kind of ATP competitive inhibitor and it can effectively inhibit the recombinant PDGFR and intracellular kinase Lyn, and FGFR3.

What are some of the in vivo effects of Masitinib?

Daily oral administration of 12.5 mg/kg Masitinib improves all TTP (the grown tumor with the time) and exhibits synergetic effects with gemcitabine to fight against the proliferation of anti-gemcitabine cell lines.

What is the storage temperature recommended for Masitinib?

Masitinib should be stored in a refrigerator.

What is the primary target of Masitinib?

The primary target of Masitinib is KIT.

What are the most common side effects of Masitinib?

The most common side effects of Masitinib are asthenia, rash, nausea, oedema, and diarrhea.

How is Masitinib different from other tyrosine kinase inhibitors?

Masitinib has better safety than other tyrosine inhibitors.

How is Masitinib used in the treatment of certain diseases?

Masitinib can be used in the treatment of multiple myeloma, gastrointestinal stromal tumors, prostate cancer, pancreatic cancer, ALS, and inflammatory diseases.

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