3-Methyladenine

Catalog Number	ACM5142234
CAS Number	5142-23-4
Description	3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K.
Synonyms	3-Methylpurin-6-amine
IUPAC Name	3-Methyl-7h-purin-6-imine
Molecular Weight	149.15
Molecular Formula	C6H7N5
Canonical SMILES	CN1C=NC(=N)C2=C1N=CN2
InChI	InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3,7H,1H3,(H,8,9)
InChI Key	ZPBYVFQJHWLTFB-UHFFFAOYSA-N
Boiling Point	240 °C
Melting Point	300 °C(lit.)
Flash Point	99 °C
Purity	98%
Density	1.60 g/cm³
Appearance	White powder
Storage	Keep in dark place, sealed in dry, room temperature
Complexity	211
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	0
Exact Mass	149.07014524
Heavy Atom Count	11
Hydrogen Bond Acceptor Count	2
Hydrogen Bond Donor Count	2
Monoisotopic Mass	149.07014524
PhysicalState	Powder
Rotatable Bond Count	0
Topological Polar Surface Area	68.1 Ų

Custom Q&A

What is the chemical formula of 3-METHYLADENINE?

The chemical formula of 3-METHYLADENINE is C6H7N5.

What is the molecular weight of 3-METHYLADENINE?

The molecular weight of 3-METHYLADENINE is 149.15.

How can 3-METHYLADENINE be stored?

3-METHYLADENINE can be stored in a dark place, sealed in dry conditions, at room temperature.

What is the solubility of 3-METHYLADENINE?

3-METHYLADENINE is soluble in DMSO (up to 3 mg/ml) or in DMF (up to 10 mg/ml).

What is the usage of 3-METHYLADENINE?

3-METHYLADENINE is used as an autophagy inhibitor by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K).

What is the general description of 3-METHYLADENINE?

3-METHYLADENINE is described as a widely used cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis following serum/potassium deprivation.

What is the safety information provided for 3-METHYLADENINE?

The Hazard Codes for 3-METHYLADENINE are Xn and the Risk Statements are 22.

What is the boiling point of 3-METHYLADENINE?

The boiling point of 3-METHYLADENINE is 240°C.

How does 3-METHYLADENINE work as an inhibitor?

3-METHYLADENINE inhibits autophagy by blocking autophagosome formation via the inhibition of type III phosphatidylinositol 3-kinases (PI-3K).

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