Neotuberostemonine

Catalog Number	ACM143120461
CAS Number	143120-46-1
Synonyms	(2S,7aR,8R,8aR,11S,11aR,11bS,11cR)-8-Ethyl-11-methyl-2-[(2S,4S)-4 -methyl-5-oxotetrahydro-2-furanyl]dodecahydroazepino[3,2,1-hi]fur o[3,2-e]indol-10(2H)-one
Molecular Weight	375.5
InChI	InChI=1S/C22H33NO4/c1-4-13-14-7-5-6-8-23-16(17-9-11(2)21(24)26-17)10-15(19(14)23)18-12(3)22(25)27-20(13)18/h11-20H,4-10H2,1-3H3/t11-,12-,13+,14+,15-,16-,17-,18-,19+,20+/m0/s1
InChI Key	GYOGHROCTSEKDY-UEIGSNQUSA-N
Purity	98%+
Complexity	636
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	10
Exact Mass	375.24095853
Heavy Atom Count	27
Hydrogen Bond Acceptor Count	5
Hydrogen Bond Donor Count	0
Isomeric SMILES	CC[C@@H]1[C@H]2CCCCN3[C@H]2[C@@H](C[C@H]3[C@@H]4C[C@@H](C(=O)O4)C)[C@H]5[C@@H]1OC(=O)[C@H]5C
Monoisotopic Mass	375.24095853
PhysicalState	Powder
Rotatable Bond Count	2
Topological Polar Surface Area	55.8 Ų

Custom Q&A

What is the chemical formula of Neotuberostemonine?

The chemical formula of Neotuberostemonine is C22H33NO4.

What is the molecular weight of Neotuberostemonine?

The molecular weight of Neotuberostemonine is 375.5 g/mol.

What is the boiling point of Neotuberostemonine?

The boiling point of Neotuberostemonine is predicted to be 554.2±50.0 °C.

What is the solubility of Neotuberostemonine in DMSO?

Neotuberostemonine is soluble in DMSO at a concentration of 10 mM.

What is the biological function of Neotuberostemonine?

Neotuberostemonine has diverse biological activities, such as inhibiting LPS-induced increases in iNOS protein levels and NO production, inhibiting osteoclast differentiation, and reducing cough reflex in guinea pigs.

What role does Neotuberostemonine have in the treatment of pulmonary fibrosis?

Neotuberostemonine has a significant protective effect on bleomycin-induced pulmonary fibrosis by suppressing the recruitment and M2 polarization of macrophages.

What is the main source of Neotuberostemonine?

Neotuberostemonine is one of the main antitussive alkaloids found in the root of Stemona tuberosa Lour.

How does Neotuberostemonine affect bronchoalveolar lavage fluid in a mouse model of pulmonary fibrosis?

Neotuberostemonine inhibits pulmonary collagen deposition and fibrosis, as well as bronchoalveolar lavage fluid monocyte and lymphocyte infiltration in a mouse model of bleomycin-induced pulmonary fibrosis.

What concentration of Neotuberostemonine is needed to inhibit RANKL-induced osteoclast differentiation in RAW 264.7 cells?

Neotuberostemonine inhibits RANKL-induced osteoclast differentiation in RAW 264.7 cells when used at a concentration of 50 μM.

How does Neotuberostemonine demonstrate its antitussive properties in guinea pigs?

Neotuberostemonine reduces the citric acid-induced cough reflex in conscious guinea pigs when administered at a dose of 133 μmol/kg.

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