Nicergoline

Catalog Number	ACM27848846
CAS Number	27848-84-6
Structure
Synonyms	10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat)
Molecular Weight	484.4
InChI	InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1
InChI Key	YSEXMKHXIOCEJA-FVFQAYNVSA-N
Melting Point	136-138 °C
Purity	98%+
Complexity	681
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	3
Exact Mass	483.11575
Heavy Atom Count	31
Hydrogen Bond Acceptor Count	5
Hydrogen Bond Donor Count	0
Isomeric SMILES	CN1C[C@@H](C[C@]2([C@H]1CC3=CN(C4=CC=CC2=C34)C)OC)COC(=O)C5=CC(=CN=C5)Br
Monoisotopic Mass	483.11575
PhysicalState	Neat
Rotatable Bond Count	5
Topological Polar Surface Area	56.6 Ų

Custom Q&A

What is the chemical formula of Nicergoline?

The chemical formula of Nicergoline is C24H26BrN3O3.

What is the melting point of Nicergoline?

The melting point of Nicergoline is 136-138°C.

What is the solubility of Nicergoline in water?

Nicergoline is practically insoluble in water.

What are the synonyms of Nicergoline?

Some synonyms of Nicergoline include Cergodum, Circo-Maren, and Dilasenil.

What is the therapeutic function of Nicergoline?

Nicergoline acts as a vasodilator.

What are the safety statements associated with Nicergoline?

The safety statements associated with Nicergoline include Risk Statements 22 and Safety Statements 36.

How is Nicergoline prepared?

Nicergoline is prepared through a multi-step process involving acylation and recrystallization from various solvents.

What are the biological activities of Nicergoline?

Nicergoline is α-adrenergic and acts as a vasodilator. It also has cognitive enhancing properties.

What are the potential therapeutic effects of Nicergoline?

Nicergoline may protect against degeneration of cholinergic neurones and has been used in the treatment of various dementias, including Alzheimer's disease and vascular dementia.

What is the brand name of Nicergoline?

The brand name of Nicergoline is Sermion.

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