Nuciferine

Catalog Number	ACM475832-3
CAS Number	475-83-2
Description	Nuciferine is a natural compound that is found in the plant Nuxia floribunda. It has been shown to have an effect on energy metabolism and inflammatory response. Nuciferine was extracted from plants by means of the in vitro method. The optimum concentration for nuciferine was determined using a preparative high performance liquid chromatography (HPLC) technique. Nuciferine also inhibited cyclase activity, which may be due to its ability to inhibit toll-like receptor 4 (TLR4).
Synonyms	1,2-Dimethoxy-6aβ-aporphine
IUPAC Name	(6aR)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
Molecular Weight	295.38 g/mol
Molecular Formula	C19H21NO2
Canonical SMILES	CN1CCC2=CC(=C(C3=C2[C@H]1CC4=CC=CC=C43)OC)OC
InChI	InChI=1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1
InChI Key	ORJVQPIHKOARKV-OAHLLOKOSA-N
Boiling Point	437.06 °C
Melting Point	165.5 °C
Purity	98%
Density	1.12 g/ml
Appearance	Yellow powder
Storage	store at 2℃-8℃
Complexity	401
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	1
Exact Mass	295.157228913
Harmonized Tariff Code	Switzerland: 29339910 - USA: 2933999701 - Slovakia: 2933991000 - UK: 2933998000 - China: 2933990000
Heavy Atom Count	22
Hydrogen Bond Acceptor Count	3
Hydrogen Bond Donor Count	0
Isomeric SMILES	CN1CCC2=CC(=C(C3=C2[C@H]1CC4=CC=CC=C43)OC)OC
MDL Number	MFCD01664592
Monoisotopic Mass	295.157228913
PhysicalState	Powder
Rotatable Bond Count	2
Topological Polar Surface Area	21.7 Ų

Custom Q&A

What is the chemical formula for Nuciferine?

The chemical formula for Nuciferine is C19H21NO2.

What is the melting point of Nuciferine?

The melting point of Nuciferine is 165.5°C.

What is the boiling point of Nuciferine?

The boiling point of Nuciferine is estimated to be 437.06°C.

What is the solubility of Nuciferine in DMSO?

Nuciferine is soluble in DMSO at a concentration of 11.11 mg/mL.

What is the color of Nuciferine in its powder form?

Nuciferine is white to beige in color in its powder form.

What is the optical activity of Nuciferine in ethanol?

The optical activity of Nuciferine is [α]/D -145 to -165°, c = 0.5 in ethanol.

What are some safety statements associated with Nuciferine?

Safety Statements include 24/25 and Toxicity LD50 orl-rat: 280 mg/kg.

What is the main usage of Nuciferine?

Nuciferine is used for weight loss and lipid reduction and can be used for content determination, identification, and pharmacological experiments.

What are some references for Nuciferine?

References include Gulland, Haworth., J. Chem. Soc., 590 (1928) and Kupchan et al., Tetrahedron, 19, 227 (1963).

What is the potential application of Nuciferine in drug development?

Nuciferine is a drug candidate for the treatment of obesity-related diseases, although its pharmacokinetics in vivo have not been fully investigated.

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