Palmatine chloride

Catalog Number	ACM10605024
CAS Number	10605-02-4
Structure
Description	Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.
Synonyms	2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride
IUPAC Name	2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride
Molecular Weight	387.86
Molecular Formula	C21H22ClNO4
Canonical SMILES	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC.[Cl-]
InChI	InChI=1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1
InChI Key	RLQYRXCUPVKSAW-UHFFFAOYSA-M
Melting Point	205 °C
Purity	98%
Appearance	Powder
Complexity	475
Covalently-Bonded Unit Count	2
Defined Atom Stereocenter Count	0
Exact Mass	387.1237359
Heavy Atom Count	27
Hydrogen Bond Acceptor Count	5
Hydrogen Bond Donor Count	0
Monoisotopic Mass	387.1237359
PhysicalState	Solid
Rotatable Bond Count	4
Topological Polar Surface Area	40.8 Ų

Custom Q&A

What are some synonyms for Palmatine chloride?

2,3,9,10-Tetramethoxyprotoberberin chloride, Berbericine chloride, Palmatine hydrochloride, Palmatine HCL, PalMatin hydrochloride, 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride

What is the CAS number for Palmatine chloride?

10605-02-4

What is the molecular formula of Palmatine chloride?

C21H22ClNO4

What are the product categories that Palmatine chloride falls under?

Chemical reagent, pharmaceutical intermediate, phytochemical, reference standards from Chinese medicinal herbs (TCM), standardized herbal extract, Inhibitors

What is the melting point of Palmatine chloride?

205℃

In what form does Palmatine chloride exist?

Solid

What is the color of Palmatine chloride?

Yellow

What is the main biological activity of Palmatine chloride?

Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), reduction of Zika virus infection in Vero cells, reduction of colonic myeloperoxidase (MPO) activity, and reduction of stomach ulcer area

What are some potential uses of Palmatine chloride?

Anti-inflammatory and anti-hypertensive agent, antibacterial, antimalarial, uterine contractant

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