Piperlongumine

Catalog Number	ACM20069094
CAS Number	20069-09-4
Structure
Description	Piperlongumine is a alkaloid, possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome.
Synonyms	1-[(E)-3-(3,4,5-Trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one
Molecular Weight	317.34
Molecular Formula	C17H19NO5
InChI	InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+
InChI Key	VABYUUZNAVQNPG-BQYQJAHWSA-N
Melting Point	124 °C
Flash Point	241.4°C
Purity	98%+
Density	1.223 g/cm³
Solubility	water, 1030 mg/L @ 25 °C (est)
Complexity	473
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	0
Exact Mass	317.12632271
Heavy Atom Count	23
Hydrogen Bond Acceptor Count	5
Hydrogen Bond Donor Count	0
Isomeric SMILES	COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCC=CC2=O
MDL Number	MFCD00075706
Monoisotopic Mass	317.12632271
PhysicalState	Powder
Rotatable Bond Count	5
Topological Polar Surface Area	65.1 Ų

Custom Q&A

What is the chemical formula for PIPERLONGUMINE?

The chemical formula for PIPERLONGUMINE is C17H19NO5.

What is the molecular weight of PIPERLONGUMINE?

The molecular weight of PIPERLONGUMINE is 317.34.

At what temperature does PIPERLONGUMINE melt?

PIPERLONGUMINE melts at 124°C.

What is the solubility of PIPERLONGUMINE in DMSO?

PIPERLONGUMINE is soluble in DMSO at a concentration of ≥5mg/mL at 60°C.

How long is PIPERLONGUMINE stable for when stored as supplied?

PIPERLONGUMINE is stable for 2 years from the date of purchase when stored as supplied.

What is the main usage of PIPERLONGUMINE in terms of studying protein regulator of cytokinesis 1 (PRC1) expression?

PIPERLONGUMINE has been used to study the regulation of protein regulator of cytokinesis 1 (PRC1) expression.

What are some of the reported health benefits of PIPERLONGUMINE?

PIPERLONGUMINE has anti-cancer, anti-atherosclerotic, anxiolytic, antidiabetic, antidepressant, antibacterial, and anti-inflammatory properties.

How does PIPERLONGUMINE selectively target and kill cancer cells?

PIPERLONGUMINE selectively targets and kills cancer cells by inhibiting proteins known to regulate oxidative stress, particularly Glutathione S-transferase pi 1 (GSTP1).

What is the general description of PIPERLONGUMINE based on its properties?

PIPERLONGUMINE is an alkaloid extracted from Piper longum Linn, with various medicinal properties such as anti-cancer, anti-inflammatory, and anti-atherosclerotic effects.

What is the main target of PIPERLONGUMINE?

The main target of PIPERLONGUMINE is P450 (e.g. CYP17) and it has antifection properties.

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