Quizartinib

Catalog Number	ACM950769581
CAS Number	950769-58-1
Structure
Synonyms	Quizartinib (AC220)
IUPAC Name	1-(5-tert-Butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea
Molecular Weight	560.67
Molecular Formula	C29H32N6O4S
Canonical SMILES	CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3
InChI	InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
InChI Key	CVWXJKQAOSCOAB-UHFFFAOYSA-N
Purity	98%+
Storage	Store in dry, low temperature, sealed, 2-8 °C.
Complexity	849
Exact Mass	560.22057470
Heavy Atom Count	40
Monoisotopic Mass	560.22057470
Topological Polar Surface Area	134Ų

Custom Q&A

What is the chemical formula of Quizartinib (AC220)?

The chemical formula of Quizartinib (AC220) is C29H32N6O4S.

What type of inhibitor is Quizartinib?

Quizartinib is a FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells.

What is the storage temperature recommended for Quizartinib?

The recommended storage temperature for Quizartinib is -20°C.

How long is Quizartinib stable for from the date of purchase?

Quizartinib is stable for 1 year from the date of purchase as supplied.

What is the solubility of Quizartinib?

Quizartinib is soluble in DMSO (up to at least 25 mg/ml).

What is the target of Quizartinib?

Flt3ITD is the target of Quizartinib.

What is the molecular weight of Quizartinib?

The molecular weight of Quizartinib is 560.67 g/mol.

What kind of leukemia is Quizartinib used for the treatment of?

Quizartinib is used for the treatment of acute myeloid leukemia (AML).

What is the HS code for Quizartinib?

The HS code for Quizartinib is 2914500090.

What are some of the features of Quizartinib?

Quizartinib is a 2nd-generation FLT3 inhibitor and a clinical drug candidate with good efficacy and high tolerability.

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