Sanguinine

Catalog Number	ACM60755808-1
CAS Number	60755-80-8
Synonyms	O-Desmethylgalantamine
Molecular Weight	273.33
InChI	InChI=1S/C16H19NO3/c1-17-7-6-16-5-4-11(18)8-13(16)20-15-12(19)3-2-10(9-17)14(15)16/h2-5,11,13,18-19H,6-9H2,1H3/t11-,13-,16-/m0/s1
InChI Key	OYSGWKOGUVOGFQ-RBOXIYTFSA-N
Melting Point	227-230 °C
Purity	90%+
Complexity	426
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	3
Exact Mass	273.13649347
Heavy Atom Count	20
Hydrogen Bond Acceptor Count	4
Hydrogen Bond Donor Count	2
Isomeric SMILES	CN1CC[C@@]23C=C[C@@H](C[C@@H]2OC4=C(C=CC(=C34)C1)O)O
Monoisotopic Mass	273.13649347
PhysicalState	Powder
Rotatable Bond Count	0
Topological Polar Surface Area	52.9 Ų

Custom Q&A

What is the chemical name of the compound with the CAS number 60755-80-8?

The chemical name of the compound is O-DESMETHYLGALANTHAMINE.

What is the molecular formula of O-DESMETHYLGALANTHAMINE?

The molecular formula is C16H19NO3.

What is the melting point of O-DESMETHYLGALANTHAMINE?

The melting point is 227-230°C.

What is the main usage of O-DESMETHYLGALANTHAMINE?

It is a metabolite of Galanthamine, which is a selective acetylcholinesterase inhibitor.

How does Sanguinine differ from Galanthamine in terms of acetylcholinesterase inhibitory activity?

Sanguinine has a more potent acetylcholinesterase inhibitory activity than galanthamine due to an extra hydroxyl group available for potential interaction with acetylcholinesterase.

What is the storage temperature recommended for O-DESMETHYLGALANTHAMINE?

The storage temperature recommended is -20°C freezer.

What is the solubility of O-DESMETHYLGALANTHAMINE in DMSO?

It is soluble in DMSO.

What is the predicted pKa of O-DESMETHYLGALANTHAMINE?

The predicted pKa is 9.39±0.40.

What is the chemical property of Sanguinine?

Sanguinine is a pale yellow powder.

How does the acetylcholinesterase inhibitory activity of Sanguinine compare to that of lycoramine and epinorlicoramine?

Sanguinine is 10-fold more selective than galanthamine for acetylcholinesterase (AChE) vs. butyrylcholinesterase (BuChE), whereas lycoramine and epinorlicoramine lack AChE inhibitory activity.

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