Severine palmitate

Catalog Number	ACM74493882
CAS Number	74493-88-2
Description	Severine is a natural product that is extracted from the leaves of Rutaceae. It has been shown to have anticancer properties against cholangiocarcinoma cells, which may be due to its ability to inhibit the proliferation and induce apoptosis in these cells. Severine is converted into severine palmitate by acetylation, forming a new molecule with antiproliferative activity. The chemical structure of severine palmitate consists of an apigenin-derived crenulata skeleton with a natural product flavone at C-6 and a diacetate ester at C-7. Severine palmitate has been shown to be effective against human cholangiocarcinoma cell lines in vitro, as well as in vivo when administered orally or intravenously.
Synonyms	O-Palmitoylseverine4- [4- [2- (Benzoylamino) ethyl] phenoxy] - 1- [(3, 3- dimethyloxiranyl) methyl] - 2- methyl- 2- butenyl ester h exadecanoic acid
Molecular Weight	647.93 g/mol
Molecular Formula	C41H61NO5

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