Sophoramine

Catalog Number	ACM6882662-1
CAS Number	6882-66-2
Description	Sophoramine is a quinolizidine alkaloid that is found in Cimicifuga foetida. It is a potent immunosuppressive agent with a number of biological studies, including lymphocyte transformation and the ability to decrease disease activity. Sophoramine has been shown to inhibit hydrochloric acid production in rats and to cause cardiac effects at high doses. It also inhibits the proliferation of cardiac cells by inhibiting protein synthesis. In addition, it has been shown to have an effect on congestive heart failure through its pharmacokinetics study. Sophoramine has a low level of toxicity due to its low solubility in human serum, which means that it does not enter the bloodstream easily.
Synonyms	11,12,13,14-Tetradehydromatridin-15-one
Molecular Weight	244.33 g/mol
Molecular Formula	C15H20N2O
Canonical SMILES	C1C[C@H]2CN3C(=O)C=CC=C3[C@@H]4[C@H]2N(C1)CCC4
InChI	InChI=1S/C15H20N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h1,6-7,11-12,15H,2-5,8-10H2/t11-,12+,15-/m0/s1
InChI Key	MMCQRJPAMIHLQX-ZOWXZIJZSA-N
Melting Point	164-165 °C
Purity	90%+
Storage	store at 10℃-25℃, close container well
Complexity	440
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	3
Exact Mass	244.157563266
Harmonized Tariff Code	Switzerland: 29420090 - USA: 2942005000 - Slovakia: 2942000090 - UK: 2942009000 - China: 2939799099
Heavy Atom Count	18
Hydrogen Bond Acceptor Count	2
Hydrogen Bond Donor Count	0
Isomeric SMILES	C1C[C@H]2CN3C(=O)C=CC=C3[C@@H]4[C@H]2N(C1)CCC4
MDL Number	MFCD01632128
Monoisotopic Mass	244.157563266
PhysicalState	Powder
Rotatable Bond Count	0
Topological Polar Surface Area	23.6 Ų

Custom Q&A

What is another name for Sophoramine?

Sophoramine is also known as 11,12,13,14-Tetradehydromatridin-15-one.

What is the molecular formula of Sophoramine?

The molecular formula of Sophoramine is C15H20N2O.

What is the melting point of Sophoramine?

The melting point of Sophoramine is 164-5°C.

What is the boiling point of Sophoramine?

The boiling point of Sophoramine is 455.6±34.0 °C (Predicted).

What is the density of Sophoramine?

The density of Sophoramine is 1.22±0.1 g/cm3 (Predicted).

What is the pKa of Sophoramine?

The pKa of Sophoramine is 9.67±0.20 (Predicted).

What are some well crystalline salts and derivatives of Sophoramine?

Some well crystalline salts and derivatives of Sophoramine include the hydrochloride, hydriodide, aurichloride, platinichloride, picrate, and picrolonate.

What is one of the traditional Chinese herbal drugs that Sophoramine is isolated from?

Sophoramine is isolated from traditional Chinese herbal drugs such as Sophora flavescens Ait.

What is the optical rotation of Sophoramine?

Sophoramine is laevorotatory with [α]D -90.85° or -98° (EtOH).

What is the characteristic structure of Sophoramine?

The base of Sophoramine possesses the tetracyclic structure characteristic of the Sophora alkaloids.

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