Tetrandrine

Catalog Number	ACM518343-2
CAS Number	518-34-3
Description	Non-selective calcium channel blocker
Synonyms	(1β)-6,6,7,12-Tetramethoxy-2,2'-dimethylberbaman
Molecular Weight	622.75 g/mol
Molecular Formula	C38H42N2O6
Canonical SMILES	CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC
InChI	InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1
InChI Key	WVTKBKWTSCPRNU-KYJUHHDHSA-N
Melting Point	219-222 °C
Purity	95%+
Storage	store at 2℃-8℃, close container well
Complexity	979
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	2
Exact Mass	622.30428706
Harmonized Tariff Code	Switzerland: 29397900 - USA: 2939790000 - Slovakia: 2939799090 - UK: 2939490090 - China: 2939799099
Heavy Atom Count	46
Hydrogen Bond Acceptor Count	8
Hydrogen Bond Donor Count	0
Isomeric SMILES	CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC
MDL Number	MFCD08689909
Monoisotopic Mass	622.30428706
PhysicalState	Solid
Rotatable Bond Count	4
Topological Polar Surface Area	61.9 Ų

Custom Q&A

What is the chemical name of D-Tetrandrine?

The chemical name of D-Tetrandrine is [4aS-(4aR*,16aR*)]-3,4,4a,5,16a,17,18,19-Octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline.

What is the molecular formula of D-Tetrandrine?

The molecular formula of D-Tetrandrine is C38H42N2O6.

What is the melting point of D-Tetrandrine?

The melting point of D-Tetrandrine is 219-222 °C.

In what solvents is D-Tetrandrine slightly soluble?

D-Tetrandrine is slightly soluble in chloroform and methanol (when heated).

What are some of the safety statements associated with D-Tetrandrine?

The safety statements associated with D-Tetrandrine include 22-24/25, 36, and 26.

What are some of the reported biological activities of Tetrandrine?

Tetrandrine has been reported to induce autophagy in certain cells, inhibit platelet aggregation, reduce TNF-α secretion, and increase glucose transporter 4 levels.

When did researchers first discover the effects of Tetrandrine on blocking the Ca2+ channel?

Researchers first discovered the effects of Tetrandrine on blocking the Ca2+ channel as early as 1988.

What are some of the historical uses of Tetrandrine in pharmacological research?

Tetrandrine has been used in pharmacological research for antihypertension, arrhythmia, myocardial ischemia, and inflammation.

How is Tetrandrine described in terms of its physical properties?

Tetrandrine is described as a white powder with needle-like crystals.

What is the clinical use of Tetrandrine?

Tetrandrine is used in clinical applications for the treatment of hypertension, angina, supraventricular tachycardia, pulmonary fibrosis, and has strong antitumor effects.

※ Please kindly note that our products are for research use only.