Triptolide

Catalog Number	ACM38748322-2
CAS Number	38748-32-2
Structure
Synonyms	Triptolid
IUPAC Name	(1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-Hydroxy-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-17-one
Molecular Weight	360.4
Molecular Formula	C20H24O6
Canonical SMILES	CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C
InChI	InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
InChI Key	DFBIRQPKNDILPW-CIVMWXNOSA-N
Melting Point	226-227 °C
Purity	98%+(HPLC)
Solubility	Soluble in water, methanol, ethyl acetate, and chloroform.
Appearance	White powder
Storage	Store at 4 °C, sealed, away from light (valid for 2 years under this condition).
Complexity	819
Exact Mass	360.15728848
Heavy Atom Count	26
Isomeric SMILES	CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C
Monoisotopic Mass	360.15728848
Topological Polar Surface Area	84.1Ų

Custom Q&A

What is the chemical formula of Triptolide?

The chemical formula of Triptolide is C20H24O6.

What are some synonyms for Triptolide?

Some synonyms for Triptolide include PG490 and TRIPOLIDE.

What are the anti-inflammatory and immunosuppressive effects of Triptolide?

Triptolide has anti-inflammatory and immunosuppressive effects, such as reducing ear edema in mice and inhibiting immune responses.

What are the anti-cancer effects of Triptolide?

Triptolide has shown good anti-tumor activity against various cancers like leukemia, breast cancer, pancreatic cancer, and lung cancer.

How can the content of Triptolide be determined using the TLCS method?

The content of Triptolide can be determined using the TLCS method by preparing a sample and reference solution, chromatographing the solutions, and calculating the content based on absorption values.

What safety statements are associated with Triptolide?

Safety Statements 22-24/25 are associated with Triptolide, indicating that it should be kept away from the reach of children and avoid contact with skin and eyes.

How does Triptolide inhibit eukaryotic transcription?

Triptolide irreversibly inhibits eukaryotic transcription by covalently binding to XPB, a subunit of the transcription factor TFIIH.

What is the mechanism by which Triptolide suppresses gene transcription?

Triptolide suppresses broad gene transcription by causing DNA damage in cells and activating the P-TEFb, which phosphorylates Rpb1, leading to its degradation.

How is Triptolide used in the treatment of rheumatoid arthritis?

Triptolide extracted from Tripterygium wilfordii is applied externally to treat rheumatoid arthritis by smashing the roots and leaves of the plant.

What are the biological activities of Triptolide?

Triptolide inhibits cytokine-induced gene expression by inhibiting NF- κ B transcriptional activity and induces apoptosis in tumor cells by blocking certain proteins.

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