Ubenimex

Catalog Number	ACM58970766-1
CAS Number	58970-76-6
Synonyms	Bestatin
IUPAC Name	(2S)-2-[[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid
Molecular Weight	308.37
Molecular Formula	C16H24N2O4
Canonical SMILES	CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O
InChI	InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
InChI Key	VGGGPCQERPFHOB-RDBSUJKOSA-N
Purity	98%+(HPLC)
Storage	Store at 4 °C, sealed, away from light (valid for 2 years under this condition).
Complexity	367
Exact Mass	308.17360725
Heavy Atom Count	22
Isomeric SMILES	CC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](CC1=CC=CC=C1)N)O
Monoisotopic Mass	308.17360725
Topological Polar Surface Area	113Ų

Custom Q&A

What is the chemical formula for Bestatin?

The chemical formula for Bestatin is C16H24N2O4.

What is the CAS number for Bestatin?

The CAS number for Bestatin is 58970-76-6.

What is the melting point of Bestatin?

The melting point of Bestatin is 245°C.

What are some synonyms for Bestatin?

Some synonyms for Bestatin include UBENIMEX, UbenaMix, Inobestin, and NK 421.

What is the origin of Bestatin?

Bestatin was originally isolated from Streptomyces olivoreticuli.

What is the primary usage of Bestatin?

Bestatin is a competitive aminopeptidase B inhibitor, primarily used in the treatment of leukemia.

How does Bestatin act as an immunomodulator?

Bestatin activates macrophages and T lymphocytes, modulating the immune response.

What is the mode of action of Bestatin in inhibiting tumor growth?

Bestatin inhibits the production of LTB4, decreases serum levels of LTB4, and reduces tumor growth in colorectal cancer models.

In which types of cancers has Bestatin shown potential for treatment?

Bestatin has shown potential for treatment in non-lymphocytic leukemia, acute myelocytic leukemia, and squamous cell lung cancer.

How does Bestatin impact the survival of patients with cancer?

Bestatin has been shown to prolong remission duration, improve overall survival, and increase cancer-free survival rates in patients with various types of cancer.

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