Vinblastine

Catalog Number	ACM865214
CAS Number	865-21-4
Synonyms	Rozevin
IUPAC Name	Methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
Molecular Weight	810.97
Molecular Formula	C46H58N4O9
Canonical SMILES	CC[C@@]1(C[C@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
InChI	InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
InChI Key	JXLYSJRDGCGARV-CFWMRBGOSA-N
Boiling Point	755.65 °C
Melting Point	211-216 °C
Purity	98%
Density	1.133 g/ml
Appearance	Powder
Complexity	1700
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	9
Exact Mass	810.42037944
Heavy Atom Count	59
Hydrogen Bond Acceptor Count	12
Hydrogen Bond Donor Count	3
Isomeric SMILES	CC[C@@]1(C[C@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
Monoisotopic Mass	810.42037944
PhysicalState	Solid
Rotatable Bond Count	10
Topological Polar Surface Area	154 Ų

Custom Q&A

What is the chemical formula of Vinblastine?

The chemical formula of Vinblastine is C46H58N4O9.

What is the appearance of Vinblastine?

Vinblastine appears as yellow needlelike crystals when recrystallized by methanol.

What is the therapeutic function of Vinblastine?

The therapeutic function of Vinblastine is cancer chemotherapy.

How does Vinblastine affect cell growth during metaphase?

Vinblastine suppresses cell growth during metaphase by inhibiting protein and nucleic acid synthesis.

What is the initial elimination half-life of Vinblastine?

The initial elimination half-life of Vinblastine is 3.7 minutes.

What is the storage temperature recommended for Vinblastine?

Vinblastine should be sealed in dry and stored in the freezer, under -20°C.

What are the synonyms of Vinblastine?

Some synonyms of Vinblastine include Vinblastine 94% BP98 and Vincristine EP Impurity H.

In which pharmacopoeias is Vinblastine recorded?

Vinblastine is recorded in the Pharmacopoeia of the People's Republic of China, the British Pharmacopoeia, the United States Pharmacopeia, the Japanese Pharmacopeia, and the European Pharmacopoeia.

What is the mechanism of action of Vinblastine?

Vinblastine suppresses cell growth during metaphase, affects amino acid metabolism, and inhibits protein and nucleic acid synthesis.

What are the main uses of Vinblastine?

Vinblastine is used for severe lymphoblastic leukemia, Hodgkin's disease, nonHodgkin's lymphoma, neuroblastoma, sarcoma, and other cancerous diseases.

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