Rhynchophylline

Rhynchophylline is an alkaloid found in several plant species, particularly in Uncaria rhynchophylla, a traditional medicinal herb used in Chinese medicine. This compound is part of the oxindole alkaloid family and has a unique structural configuration which includes a tricyclic skeleton, incorporating a tetrahydrofuran ring fused with a piperidine ring. Rhynchophylline has been the subject of research due to its diverse pharmacological properties.

Alfa Chemistry offers high-quality rhynchophylline for research and development purposes.

Product Detail

Product Name	Rhynchophylline
CAS No.	76-66-4
Catalog	ALKS76664
Molecular Weight	384
Molecular Formula	C22H28N2O4
Purity	≥ 98%
Appearance	White crystalline powder
Melting Point	216 °C
Extract Source	Uncaria rhynchophylla (Miq.) Jacks.
Solubility	Soluble in chloroform, acetone, ethanol, benzene, slightly soluble in ether and ethyl acetate, insoluble in petroleum ether.
Application	Used for content determination, identification, pharmacological experiments, activity screening, etc.
Storage	Refrigerate at 4 °C, seal tightly, and avoid light (valid for 2 years under this condition).

Bioactive Properties and Mechanism of Action

Neuroprotection

Rhynchophylline modulates NMDA (N-methyl-D-aspartate) receptors, which play a crucial role in synaptic plasticity and memory function. By inhibiting these receptors, it can reduce excitotoxicity, a process that leads to neuronal damage. It also inhibits calcium influx into neurons, which is critical in preventing neuronal death and dysfunction.

Cardiovascular Effects

Rhynchophylline blocks calcium channels, which helps in vasodilation and reducing blood pressure. It inhibits the action of thromboxane A2, a compound that promotes platelet aggregation, thus reducing the risk of clot formation.

Anti-inflammatory Action

Rhynchophylline suppresses the expression of pro-inflammatory cytokines and mediators like TNF-α, IL-1β, and COX-2. It inhibits the activation of NF-κB, a transcription factor that regulates the inflammatory response.

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