Wilfordine

Wilfordine is a natural alkaloid compound isolated from the roots of the plant Tripterygium wilfordii, commonly known as Thunder God Vine. This plant has been traditionally used in Chinese medicine for its anti-inflammatory and immunosuppressive properties. Wilfordine belongs to the class of diterpenoid alkaloids. It has a complex polycyclic structure that includes several fused rings, characteristic of many biologically active natural products.

Alfa Chemistry offers high-quality wilfordine for research and development purposes.

Product Detail

Product Name	Wilfordine
CAS No.	37239-51-3
Catalog	ALKS37239513
Molecular Weight	883.84
Molecular Formula	C43H49NO19
Purity	≥ 98%
Appearance	White powder
Melting Point	175 - 176 °C
Extraction Source	The roots of Tripterygium wilfordii Hook. f.
Solubility	Soluble in chloroform, dichloromethane, ethyl acetate, DMSO, acetone, etc.

Applications of Wilfordine

Anti-inflammatory

Wilfordine has shown significant anti-inflammatory effects. It is capable of inhibiting the production of pro-inflammatory cytokines and reducing inflammation in various animal models.

Immunosuppressive

Due to its ability to suppress the immune system, wilfordine is of interest in treating autoimmune diseases. It has potential applications in conditions like rheumatoid arthritis and systemic lupus erythematosus.

Anti-cancer

Preliminary studies suggest that wilfordine may possess anti-cancer properties. It has been observed to induce apoptosis (programmed cell death) in certain cancer cell lines.

Neuroprotective

Mechanism of Action

The precise mechanism of action of wilfordine is complex and multifaceted, involving several biochemical pathways:

NF-κB Inhibition: Wilfordine inhibits the NF-κB pathway, which plays a critical role in regulating the immune response to infection. By suppressing NF-κB activity, wilfordine reduces the expression of various inflammatory cytokines and adhesion molecules.
MAPK Pathway Modulation: The mitogen-activated protein kinase (MAPK) pathway is another target of wilfordine. This pathway is involved in cellular responses to stress and inflammation. Wilfordine's modulation of the MAPK pathway contributes to its anti-inflammatory and immunosuppressive effects.
Induction of Apoptosis: In cancer cells, wilfordine has been shown to induce apoptosis. This is achieved through the activation of caspases, a family of enzymes that play essential roles in programmed cell death, and the regulation of pro-apoptotic and anti-apoptotic proteins.
Reactive Oxygen Species (ROS) Production: Wilfordine can increase the production of ROS within cells. This increase in oxidative stress can trigger apoptosis in cancer cells and other targeted cells.
Inhibition of Pro-inflammatory Cytokines: Wilfordine decreases the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, which are critical mediators of inflammation.

Research and Development

Wilfordine is a multifaceted compound with significant potential in various therapeutic areas. It is still under active research to fully understand its pharmacokinetics, pharmacodynamics, and potential therapeutic applications. Clinical trials and further studies are necessary to confirm its efficacy and safety in humans.

Choose Alfa Chemistry

At Alfa Chemistry, we are dedicated to offering industry-leading alkaloid products. Our top-quality wilfordine stands as a dependable choice for researchers and scientists. If you are in need of this exceptional compound, don't hesitate to reach out to us today.