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Vincristine is dimeric alkaloid isolated from the Madagaskar periwinkle plant (Catharantus roseus). Its molecular weight is 824.96 kDa, and the empirical formula is C46H56N4O10. Vincristine exhibits significant cytotoxic activity and is used as an antineoplastic agent in antitumor therapy. During cell proliferation, vincristine exerts its anti-neoplastic efect by inhibiting polymerization of tubulin and incorporation into microtubules, which prevents mitotic spindle assembly, leading to extension of mitosis and thereby apoptosis. In tumor cells, vincristine inhibits DNA repair and RNA synthesis mechanisms and blocks DNA-dependent RNA polymerase. In combination with other anti-cancer drugs, vincristine is widely used to treat various cancers, such as acute lymphoblastic leukemia (ALL), malignant melanoma and breast cancer.
Figure 1. The chemical structure of vincristine.
As an expert in the field of alkaloids, Alfa Chemistry can provide detection services not only for vincristine, but also for related compounds, including vinblastine, vinblastine sulfate, leurosine, etc. We have an experienced team that can customize testing solutions to meet the needs of our customers and make them feel the quality of service experience. The professional laboratory platform that we have is the basis for us to achieve accurate detection. Our detection services include but are not limited to the following.
Our detection platforms include but are not limited to the following.
Our detection service has many advantages. The main advantages are as follows.
Customer satisfaction is the goal that we constantly pursue. We promise you that when the project starts, our technicians will draw up a detection plan suitable for you as soon as possible. During the project, we will maintain effective communication with you in order to keep you updated on the progress of the project. When the project is completed, we provide you with a professional detection report, and if you have any questions, you can consult our technical staff.
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