Berberine chloride hydrate

Catalog Number	ACM68030182-1
CAS Number	68030-18-2
Description	Berberine is a natural compound found in the roots and rhizomes of plants from the genus Berberis. It has been used for centuries in traditional Chinese medicine for the treatment of gastrointestinal problems, including diarrhea, dysentery, and cholera. Berberine chloride hydrate is an antimicrobial agent that targets tissue containing adenine nucleotides. It has been shown to reduce levels of glutamate and fatty acids in animal models at high doses as well as to increase ATP production in mitochondria at low doses. This drug also inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conj
Molecular Weight	389.8 g/mol
Molecular Formula	C20H20ClNO5
Canonical SMILES	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.O.[Cl-]
MDL Number	MFCD00149997

Custom Q&A

What is the product name of Berberine chloride hydrate?

The product name of Berberine chloride hydrate is Berberine chloride hydrate.

Where is Berberine chloride hydrate commonly isolated from?

Berberine chloride hydrate is commonly isolated from Chinese herbal medicine Coptis chinensis.

What is the storage temperature recommended for Berberine chloride hydrate?

The recommended storage temperature for Berberine chloride hydrate is -20°C.

What is the solubility of Berberine chloride hydrate in DMSO?

Berberine chloride hydrate is at least 3.9 mg/mL (10.00 mM) soluble in DMSO.

What biological activity is associated with Berberine chloride hydrate?

Berberine chloride hydrate is commonly used as an antibiotic and induces reactive oxygen species (ROS) generation while inhibiting DNA topoisomerase.

Which cell lines were tested for the inhibitory effects of Berberine chloride hydrate on cell proliferation?

Four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29 were tested for the inhibitory effects of Berberine chloride hydrate on cell proliferation.

What was the effect of Berberine chloride hydrate on the cell cycle of LoVo cells?

Exposure to 40.0 μM of Berberine chloride hydrate induced G2/M-phase cell cycle arrest in LoVo cells.

What is the range of IC50 values for Berberine chloride hydrate on different cell lines?

The IC50 values for Berberine chloride hydrate ranged from 40.8±4.1 μM for LoVo cells to 98.6±2.9 μM for HCT116 cells.

What is the concentration range at which Berberine chloride hydrate inhibits cell proliferation?

Berberine chloride hydrate inhibits cell proliferation at concentrations ranging from 1.25 to 160 μM.

How does the protein expression of cyclin B1, cdc2, and cdc25c change in response to Berberine chloride hydrate treatment?

Berberine chloride hydrate suppresses cyclin B1, cdc2, and cdc25c protein expression, especially at higher doses such as 80.0 μM after 24 hours of treatment.

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