Bruceine A

Catalog Number	ACM25514312-1
CAS Number	25514-31-2
Structure
Description	Bruceine A is a natural compound that is extracted from the root of Astragalus membranaceus. Bruceine A has been shown to have anticancer and anti-inflammatory activities in vitro. It inhibits cancer cells by binding to hydroxyl groups on their surfaces, inhibiting cellular respiration and inducing apoptosis. The compound also has anti-hepatitis and anti-cancer effects in vivo. Bruceine A inhibits the growth of hepatic cancer cells by suppressing the synthesis of fatty acids, which are necessary for cell proliferation. Bruceine A also inhibits cervical cancer cell proliferation by inhibiting the production of proteins that promote tumor growth.
Canonical SMILES	CC1=C(C(=O)C[C@]2([C@H]1C[C@@H]3[C@]45[C@@H]2[C@H]([C@@H]([C@]([C@@H]4[C@H](C(=O)O3)OC(=O)CC(C)C)(OC5)C(=O)OC)O)O)C)O
MDL Number	MFCD28167765

Custom Q&A

What is the chemical formula of bruceine A?

The chemical formula of bruceine A is C26H34O11.

What is the molecular weight of bruceine A?

The molecular weight of bruceine A is 522.54.

What is the solubility of bruceine A?

Bruceine A is insoluble in ethanol and water, but it is soluble in DMSO with gentle warming.

What are the physiological effects of bruceine A?

Bruceine A has shown effects in treating malignant tumors, acting as an antimalarial, and anti-inflammatory agent.

What is the biological activity of bruceine A?

Bruceine A acts as an anti-babesial quassinoid, extracted from the fruits of Brucea javanica, and is also an effective anti-trypanosomal agent in vitro.

How does bruceine A inhibit the growth of Babesia gibsoni in vitro?

Bruceine A inhibits the growth of Babesia gibsoni in canine erythrocytes at a lower concentration compared to the antibabesial drug diminazene aceturate and kills the parasites within 24 hours at a concentration of 25 nm.

What is the target of bruceine A in its antifection activity?

The targets of bruceine A in its antifection activity include p65, NF-kB, and ROS.

What are the physiological findings of oral administration of bruceine A in dogs?

Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in dogs, while untreated dogs developed typical acute babesiosis symptoms.

How is bruceine A derived?

Bruceine A is derived from the fruit of Brucea chinensis and is a white crystalline powder soluble in methanol, ethanol, DMSO, and other organic solvents.

How does bruceine A compare to other antibabesial drugs in terms of efficacy?

Bruceine A showed efficacy in inhibiting the growth of Babesia gibsoni parasites at a lower concentration compared to the antibabesial drug diminazene aceturate in vitro.

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