Castanospermine

Catalog Number	ACM79831768-1
CAS Number	79831-76-8
Description	Plant alkaloid and inhibitor of α- and β-glucosidases. It has anti-diabetic potential since its inhibitory activity on α-glucosidases helps control the postprandial blood glucose levels and supresses hyperglycemia. The compound exhibits anti-viral activity against Dengue, Influenza, HIV and Herpes Simplex viruses thanks to its ability to interfere with folding of viral structural glycoproteins.
Synonyms	1,6,7,8-Tetrahydroxyoctahydroindolizine
Molecular Weight	189.2 g/mol
Molecular Formula	C8H15NO4
Canonical SMILES	C1CN2C[C@@H]([C@H]([C@@H]([C@H]2[C@H]1O)O)O)O
Storage	store at 2℃-8℃
Harmonized Tariff Code	Switzerland: 29339980 - USA: 2933999701 - Slovakia: 2933998025 - UK: 2933998090 - China: 2933990099
MDL Number	MFCD00017555

Custom Q&A

What is the chemical formula of Castanospermine?

The chemical formula of Castanospermine is C8H15NO4.

What is the Melting point of Castanospermine?

The melting point of Castanospermine is 213-217 °C.

How does Castanospermine affect glucosidases?

Castanospermine is an inhibitor of both α- and β-glucosidases, affecting protein trafficking and cell functions that are dependent on glycosylation.

What are the safety codes associated with Castanospermine?

Castanospermine has hazard codes Xn, Xi and risk statements 20/21/22-36/37/38.

How is Castanospermine stored?

Castanospermine should be sealed in dry conditions at 2-8°C.

What is the specific rotation of Castanospermine?

The specific rotation of Castanospermine is +79.7°.

How does Castanospermine inhibit viral replication?

Castanospermine interferes with viral replication and infection that is dependent on glucosidase activity.

What are the different biological activities of Castanospermine?

Castanospermine is a potent inhibitor of α - and β -glucosidases, inhibits HIV syncytium formation and replication, and also inhibits inflammation.

How is Castanospermine used in angiogenesis research?

Castanospermine alters endothelial cell glycosylation, preventing angiogenesis, and inhibiting tumor growth.

What are the references that discuss the effects of Castanospermine on glucosidases and virus infectivity?

References such as Saul et al. (1984), Gruters et al. (1987), and Repp et al. (1985) discuss the mechanisms and effects of Castanospermine on glucosidases and virus infectivity.

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