Dehydroevodiamine

Catalog Number	ACM67909493-1
CAS Number	67909-49-3
Description	Dehydroevodiamine is a natural compound found in the Chinese herb Fructus Evodiae. It has been shown to have significant effects on systolic and diastolic blood pressure, as well as energy metabolism. It also has antimicrobial activity against bacteria that are resistant to antibiotics. Dehydroevodiamine inhibits acetylcholinesterase (AChE) activity, which may help to alleviate symptoms of Alzheimer's disease and other autoimmune diseases. Dehydroevodiamine can also inhibit mitochondrial membrane potential, which may be beneficial for the treatment of cancer cells.
Synonyms	8,13-Dihydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolinium inner salt
Molecular Weight	301.3
Molecular Formula	C19H15N3O
Canonical SMILES	CN1C2=CC=CC=C2C(=O)N3C1=C4C(=C5C=CC=CC5=N4)CC3
InChI	InChI=1S/C19H15N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9H,10-11H2,1H3
InChI Key	VXHNSVKJHXSKKM-UHFFFAOYSA-N
Melting Point	190-192 °C
Purity	98%+
Complexity	753
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	0
Exact Mass	301.12151211
Heavy Atom Count	23
Hydrogen Bond Acceptor Count	3
Hydrogen Bond Donor Count	0
MDL Number	MFCD11656140
Monoisotopic Mass	301.12151211
PhysicalState	Solid
Rotatable Bond Count	0
Topological Polar Surface Area	35.9 Ų

Custom Q&A

What is the chemical formula of dehydroevodiamine?

The chemical formula of dehydroevodiamine is C19H15N3O.

What is the molecular weight of dehydroevodiamine?

The molecular weight of dehydroevodiamine is 301.35.

What is the melting point of dehydroevodiamine?

The melting point of dehydroevodiamine is 190-192℃.

In which solvents is dehydroevodiamine soluble?

Dehydroevodiamine is soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO, and Acetone.

What is the storage temperature recommended for dehydroevodiamine?

The recommended storage temperature for dehydroevodiamine is 2-8°C.

From which plant is dehydroevodiamine derived from?

Dehydroevodiamine is derived from the dried near-ripe fruit of Evodia sclerosus.

What is the biological activity of dehydroevodiamine?

Dehydroevodiamine displays butyrylcholinesterase inhibitory activity in vivo.

What physiological effects are associated with dehydroevodiamine?

Dehydroevodiamine has antihypertensive and antitumor effects.

How does dehydroevodiamine inhibit iNOS and COX-2 expression in vitro?

Dehydroevodiamine inhibits LPS-induced iNOS and COX-2 expression and prevents degradation of IκB-α in RAW 264.7 macrophages.

What target molecules are affected by dehydroevodiamine?

Dehydroevodiamine affects NF-κB, COX-2, iNOS, and PGE2 molecules.

※ Please kindly note that our products are for research use only.