DL-Tetrahydropalmatine

Catalog Number	ACM2934976-1
CAS Number	2934-97-6
Structure
Description	DL-Tetrahydropalmatine is a plant alkaloid that has a wide range of pharmacological activities. It has been shown to have an inhibitory effect on the release of proinflammatory cytokines and nitric oxide, which is mediated by the activation of toll-like receptor 4 (TLR4). Tetrahydropalmatine also has an anti-inflammatory effect on the kidneys by inhibiting the production of reactive oxygen species and TNF-α. In addition, tetrahydropalmatine has a relaxant effect on smooth muscle cells and acts as an analgesic through its inhibition of NMDA receptors. This compound is also found in glycol ethers, which are used as solvents in paint removers.
Molecular Weight	355.43 g/mol
Molecular Formula	C21H25NO4
Canonical SMILES	COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC
Storage	store at 2℃-8℃
Harmonized Tariff Code	Switzerland: 29339910 - USA: 2933999701 - Slovakia: 2933991000 - UK: 2933998000 - China: 2933990000
MDL Number	MFCD00214191

Custom Q&A

What is the chemical structure of DL-Tetrahydropalmatine?

The chemical structure of DL-Tetrahydropalmatine is C21H25NO4.

What is the appearance of DL-Tetrahydropalmatine?

DL-Tetrahydropalmatine appears as a white to pale yellow solid.

What is the main active substance of the Chinese herb corydalis?

The main active substance of the Chinese herb corydalis is DL-Tetrahydropalmatine.

What are some of the uses of DL-Tetrahydropalmatine according to the reference?

DL-Tetrahydropalmatine is used as an analgesic and hypnotic substance that possesses a papaverine-like effect.

How is DL-Tetrahydropalmatine prepared from palmatine?

DL-Tetrahydropalmatine is prepared from palmatine by racemizing palmatine under the conditions of methanol and sodium borohydride.

What is the safety information regarding DL-Tetrahydropalmatine?

No specific safety information regarding DL-Tetrahydropalmatine is provided in the given reference.

What are the chemical properties of DL-Tetrahydropalmatine?

DL-Tetrahydropalmatine has a melting point of 155℃, a density of 1.23±0.1 g/cm3, and is slightly soluble in chloroform and methanol when heated or sonicated.

How does DL-Tetrahydropalmatine act in inhibiting amygdaloid release of dopamine?

DL-Tetrahydropalmatine acts through the inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.

What is the in vivo research on the effects of DL-Tetrahydropalmatine?

In vivo research has shown that a pretreatment of rats with Tetrahydropalmatine significantly attenuated Picrotoxin-induced enhancements in various activity measures.

What is the chemical formula and molecular weight of DL-Tetrahydropalmatine?

The chemical formula of DL-Tetrahydropalmatine is C21H25NO4, and its molecular weight is 355.43.

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