Glycyrrhetinic acid

Catalog Number	ACM471534-2
CAS Number	471-53-4
Synonyms	Glycyrrhetic acid
IUPAC Name	(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-Hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
Molecular Weight	470.7
Molecular Formula	C30H46O4
Canonical SMILES	CC1(C2CCC3(C(C2(CCC1O)C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C
InChI	InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1
InChI Key	MPDGHEJMBKOTSU-YKLVYJNSSA-N
Melting Point	281-285 °C
Purity	98%+(HPLC)
Appearance	White powder
Storage	Store at 4 °C, sealed, away from light (valid for 2 years under this condition).
Complexity	965
Exact Mass	470.33960994
Heavy Atom Count	34
Isomeric SMILES	C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)O
Monoisotopic Mass	470.33960994
Topological Polar Surface Area	74.6Ų

Custom Q&A

What is the chemical formula of Glycyrrhetinic acid?

The chemical formula of Glycyrrhetinic acid is C30H46O4.

What is the melting point of Glycyrrhetinic acid?

The melting point of Glycyrrhetinic acid is 292-295 °C.

In which solvents is Glycyrrhetinic acid soluble?

Glycyrrhetinic acid is soluble in ethanol and sparingly soluble in methylene chloride.

What are some potential uses of Glycyrrhetinic acid?

Glycyrrhetinic acid may be used to prepare derivatives with anti-inflammatory and antioxidant properties. It also has anti-inflammatory, antibacterial, and skin-lightening properties.

What are some safety considerations for Glycyrrhetinic acid?

Glycyrrhetinic acid has a LD50 of 308mg/kg in mice. It may pose risks of skin irritation and toxicity.

How is Glycyrrhetinic acid metabolized in the body?

Thirty percent of Glycyrrhetinic acid can be effectively used by the body, and it undergoes metabolism with hydroxylation.

What is one traditional use of Glycyrrhetinic acid in Chinese medicine?

Glycyrrhetinic acid is an important ingredient in liquorice, which is used to strengthen bones and muscles, enhance metabolism and detoxification, and improve abnormal symptoms and wounds.

What is the chemical structure of Glycyrrhetinic acid?

Glycyrrhetinic acid is a pentacyclic triterpenoid with a hydroxy group at position 3, an oxo group at position 11, and a carboxy group at position 30.

How does Glycyrrhetinic acid exhibit anti-inflammatory properties?

Glycyrrhetinic acid inhibits the activity of phospholipase A2 and lipoxygenase to reduce inflammation mediators, and it promotes antiulcer activity through the production of PGE2 and gastric mucus secretion.

What are some potential pharmacological activities of Glycyrrhetinic acid?

Glycyrrhetinic acid has anti-inflammatory, antiulcer, antioxidative, antiviral, antitumor, antiarrhythmic, and anticoagulant effects, and it may improve insulin absorption, inner ear hearing, and more.

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